Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis
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Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis. / Sørensen, Torben Lykke; Roed, Hanne; Sellebjerg, Finn.
In: Journal of Neuroimmunology, Vol. 122, No. 1-2, 01.2002, p. 125-31.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis
AU - Sørensen, Torben Lykke
AU - Roed, Hanne
AU - Sellebjerg, Finn
PY - 2002/1
Y1 - 2002/1
N2 - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.
AB - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.
KW - Adjuvants, Immunologic
KW - Adult
KW - B-Lymphocytes
KW - Cerebrospinal Fluid
KW - Demyelinating Diseases
KW - Female
KW - Flow Cytometry
KW - Humans
KW - Interferon-beta
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis, Chronic Progressive
KW - Multiple Sclerosis, Relapsing-Remitting
KW - Receptors, CCR5
KW - Receptors, CXCR3
KW - Receptors, CXCR5
KW - Receptors, Chemokine
KW - Receptors, Cytokine
M3 - Journal article
C2 - 11777551
VL - 122
SP - 125
EP - 131
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -
ID: 111410738