Changes in left ventricular filling parameters before and after dialysis in patients with end stage renal disease
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Changes in left ventricular filling parameters before and after dialysis in patients with end stage renal disease. / Ersbøll, Mads; Raja, Anna Axelsson; Warming, Peder Emil; Nielsen, Ture Lange; Plesner, Louis Lind; Dalsgaard, Morten; Schou, Morten; Rydahl, Casper; Brandi, Lisbet; Iversen, Kasper.
In: International Journal of Cardiovascular Imaging, Vol. 35, No. 9, 2019, p. 1673-1681.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Changes in left ventricular filling parameters before and after dialysis in patients with end stage renal disease
AU - Ersbøll, Mads
AU - Raja, Anna Axelsson
AU - Warming, Peder Emil
AU - Nielsen, Ture Lange
AU - Plesner, Louis Lind
AU - Dalsgaard, Morten
AU - Schou, Morten
AU - Rydahl, Casper
AU - Brandi, Lisbet
AU - Iversen, Kasper
PY - 2019
Y1 - 2019
N2 - The aim of this study was to investigate the grading of diastolic dysfunction (DD) in relation to hemodialysis in patients with end stage renal disease (ESRD) on hemodialysis (HD) Cardiovascular disease is prevalent in patients with ESRD and accounts for significant morbidity and mortality. Left ventricular hypertrophy (LVH) is common in ESRD but little is known about the impact of HD on currently recommended grading schemes for DD. Comprehensive echocardiographic data was obtained in consecutive patients with ESRD before (n = 247) and immediately after (n = 239) standard HD regimen. Grading of DD was performed according to current recommendations both pre- and post HD. Prior to HD, DD was classified as present in 83 patients (34%), indeterminate in 51 patients (21%) and absent in 113 patients (45%). Patients with DD at baseline compared to those without were older [67.3 years (13.1) vs. 63.2 (14.3), p = 0.037], were more likely to have diabetic- or hypertensive ESRD (43.4% vs. 35.4%, p = ns) and LVMi was significantly higher [119 g/cm2 (27.5) vs. 103 g/cm2 (24.3), p < 0.001]. After HD [mean HD time = 221 min (27.6), mean ultrafiltration volume = 2 L (1.1)], 39 patients (16%) exhibited sustained DD. These patients were older [69.4 years (14.5) vs. 65.0 years (13.9), p = 0.071], were more likely to have diabetic- or hypertensive ESRD (59% vs. 36%, p = 0.010). Myocardial adverse remodeling was more advanced with higher LVMi [127.4 g/m2 (27.5) vs. 106.5 g/m2 (25.3), p < 0.001], lower LVEF [44.7% (11.0) vs. 54.5% (8.7), p < 0.001] and more impaired GLS [- 13.4% (4.3) vs. - 15.8% (4.0), p = 0.006]. Echocardiographic evaluation of diastolic function in patients with ESRD on HD is critically dependent on timing relative to dialysis. The presence of sustained DD after volume unloading by HD identifies a population of patients with an adverse phenotype of blunted vascular response and severe cardiac remodeling.
AB - The aim of this study was to investigate the grading of diastolic dysfunction (DD) in relation to hemodialysis in patients with end stage renal disease (ESRD) on hemodialysis (HD) Cardiovascular disease is prevalent in patients with ESRD and accounts for significant morbidity and mortality. Left ventricular hypertrophy (LVH) is common in ESRD but little is known about the impact of HD on currently recommended grading schemes for DD. Comprehensive echocardiographic data was obtained in consecutive patients with ESRD before (n = 247) and immediately after (n = 239) standard HD regimen. Grading of DD was performed according to current recommendations both pre- and post HD. Prior to HD, DD was classified as present in 83 patients (34%), indeterminate in 51 patients (21%) and absent in 113 patients (45%). Patients with DD at baseline compared to those without were older [67.3 years (13.1) vs. 63.2 (14.3), p = 0.037], were more likely to have diabetic- or hypertensive ESRD (43.4% vs. 35.4%, p = ns) and LVMi was significantly higher [119 g/cm2 (27.5) vs. 103 g/cm2 (24.3), p < 0.001]. After HD [mean HD time = 221 min (27.6), mean ultrafiltration volume = 2 L (1.1)], 39 patients (16%) exhibited sustained DD. These patients were older [69.4 years (14.5) vs. 65.0 years (13.9), p = 0.071], were more likely to have diabetic- or hypertensive ESRD (59% vs. 36%, p = 0.010). Myocardial adverse remodeling was more advanced with higher LVMi [127.4 g/m2 (27.5) vs. 106.5 g/m2 (25.3), p < 0.001], lower LVEF [44.7% (11.0) vs. 54.5% (8.7), p < 0.001] and more impaired GLS [- 13.4% (4.3) vs. - 15.8% (4.0), p = 0.006]. Echocardiographic evaluation of diastolic function in patients with ESRD on HD is critically dependent on timing relative to dialysis. The presence of sustained DD after volume unloading by HD identifies a population of patients with an adverse phenotype of blunted vascular response and severe cardiac remodeling.
KW - Aged
KW - Diastole
KW - Echocardiography, Doppler, Color
KW - Echocardiography, Doppler, Pulsed
KW - Female
KW - Humans
KW - Hypertrophy, Left Ventricular/diagnostic imaging
KW - Kidney/physiopathology
KW - Kidney Failure, Chronic/diagnosis
KW - Male
KW - Middle Aged
KW - Predictive Value of Tests
KW - Renal Dialysis
KW - Risk Factors
KW - Severity of Illness Index
KW - Stroke Volume
KW - Time Factors
KW - Treatment Outcome
KW - Ventricular Dysfunction, Left/diagnostic imaging
KW - Ventricular Function, Left
KW - Ventricular Remodeling
U2 - 10.1007/s10554-019-01619-4
DO - 10.1007/s10554-019-01619-4
M3 - Journal article
C2 - 31093896
VL - 35
SP - 1673
EP - 1681
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
SN - 1569-5794
IS - 9
ER -
ID: 233590112