Changes in circulating metabolites during weight loss are associated with adiposity improvement, and body weight and adiposity regain during weight loss maintenance: The SATIN study
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Changes in circulating metabolites during weight loss are associated with adiposity improvement, and body weight and adiposity regain during weight loss maintenance: The SATIN study. / Papandreou, Christopher; García-Gavilán, Jesús; Camacho-Barcia, Lucía; Hansen, Thea Toft; Harrold, Joanne A; Sjödin, Anders; Halford, Jason C G; Bulló, Mónica.
In: Molecular Nutrition & Food Research, Vol. 65, No. 17, 2001154, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Changes in circulating metabolites during weight loss are associated with adiposity improvement, and body weight and adiposity regain during weight loss maintenance: The SATIN study
AU - Papandreou, Christopher
AU - García-Gavilán, Jesús
AU - Camacho-Barcia, Lucía
AU - Hansen, Thea Toft
AU - Harrold, Joanne A
AU - Sjödin, Anders
AU - Halford, Jason C G
AU - Bulló, Mónica
N1 - Funding Information: The SATIN project is funded by a grant of the Seventh Framework Programme for “Cooperation”: Food, Agriculture and Biotechnology of the European Union (2012–2016) (grant number 289800). CP is recipient of the Instituto de Salud Carlos III Miguel Servet fellowship (grant CP 19/00189). LC‐B is the recipient of a pre‐doctoral fellowship from the Generalitat de Catalunya's Department of Universities (FI‐DGR 2017). JFG‐G has received the Contratos Predoctorales de Formaciónen Investigaciónen Salud (PFIS FI17/00255) of Acción Estratégicaen Salud program (AES) from the Institute of Health Carlos III (ISCIII), Spanish Ministry of Health. Publisher Copyright: © 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH
PY - 2021
Y1 - 2021
N2 - Scope: To examine the relationship between changes in circulating metabolites during diet-induced weight loss and changes of adiposity. This study also investigates changes in these metabolites in relation to body weight and adiposity regain during a weight loss maintenance period. Methods and Results: This cohort study is nested within the Satiety Innovation (SATIN) study. Participants (n = 162) achieving ≥8% weight loss during an initial 8-week low-calorie formula diet (LCD) are included in a 12-week weight loss maintenance period. A targeted metabolite profiling (123 metabolites) approach is applied using three different platforms (proton nuclear magnetic resonance, liquid chromatography mass spectrometry, gas chromatography mass spectrometry). Changes in several lipid species and citric acid are significantly associated with greater reduction of body weight, total fat, and abdominal adiposity distribution during the LCD. Decreases in the concentrations of lysophosphatidylcholines (LPCs) 14:0, LPC 20:3, phosphatidylcholine (PC) 32:2, PC 38:3, sphingomyelin (SM) 32:2, and increases in citric acid concentrations during the LCD are associated with adiposity regain and loss, respectively, during the weight loss maintenance period. Conclusions: The results show that weight loss is associated with changes in lipid species and citric acid. These changes are related to subsequent weight and adiposity regain identifying the adipose lipid metabolism as an important factor for the maintenance of lost weight and adiposity.
AB - Scope: To examine the relationship between changes in circulating metabolites during diet-induced weight loss and changes of adiposity. This study also investigates changes in these metabolites in relation to body weight and adiposity regain during a weight loss maintenance period. Methods and Results: This cohort study is nested within the Satiety Innovation (SATIN) study. Participants (n = 162) achieving ≥8% weight loss during an initial 8-week low-calorie formula diet (LCD) are included in a 12-week weight loss maintenance period. A targeted metabolite profiling (123 metabolites) approach is applied using three different platforms (proton nuclear magnetic resonance, liquid chromatography mass spectrometry, gas chromatography mass spectrometry). Changes in several lipid species and citric acid are significantly associated with greater reduction of body weight, total fat, and abdominal adiposity distribution during the LCD. Decreases in the concentrations of lysophosphatidylcholines (LPCs) 14:0, LPC 20:3, phosphatidylcholine (PC) 32:2, PC 38:3, sphingomyelin (SM) 32:2, and increases in citric acid concentrations during the LCD are associated with adiposity regain and loss, respectively, during the weight loss maintenance period. Conclusions: The results show that weight loss is associated with changes in lipid species and citric acid. These changes are related to subsequent weight and adiposity regain identifying the adipose lipid metabolism as an important factor for the maintenance of lost weight and adiposity.
KW - Metabolomics
KW - SATIN
KW - Weight loss
KW - Weight maintenance
UR - http://www.scopus.com/inward/record.url?scp=85110999964&partnerID=8YFLogxK
U2 - 10.1002/mnfr.202001154
DO - 10.1002/mnfr.202001154
M3 - Journal article
C2 - 34184401
AN - SCOPUS:85110999964
VL - 65
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
SN - 1613-4125
IS - 17
M1 - 2001154
ER -
ID: 275431078