Cerebrovascular aspects of converting-enzyme inhibition II: Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cerebrovascular aspects of converting-enzyme inhibition II : Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril. / Jarden, J O; Barry, D I; Juhler, M; Graham, D I; Strandgaard, S; Paulson, O B.

In: Journal of Hypertension, Vol. 2, No. 6, 12.1984, p. 599-604.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jarden, JO, Barry, DI, Juhler, M, Graham, DI, Strandgaard, S & Paulson, OB 1984, 'Cerebrovascular aspects of converting-enzyme inhibition II: Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril', Journal of Hypertension, vol. 2, no. 6, pp. 599-604. https://doi.org/10.1097/00004872-198412000-00004

APA

Jarden, J. O., Barry, D. I., Juhler, M., Graham, D. I., Strandgaard, S., & Paulson, O. B. (1984). Cerebrovascular aspects of converting-enzyme inhibition II: Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril. Journal of Hypertension, 2(6), 599-604. https://doi.org/10.1097/00004872-198412000-00004

Vancouver

Jarden JO, Barry DI, Juhler M, Graham DI, Strandgaard S, Paulson OB. Cerebrovascular aspects of converting-enzyme inhibition II: Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril. Journal of Hypertension. 1984 Dec;2(6):599-604. https://doi.org/10.1097/00004872-198412000-00004

Author

Jarden, J O ; Barry, D I ; Juhler, M ; Graham, D I ; Strandgaard, S ; Paulson, O B. / Cerebrovascular aspects of converting-enzyme inhibition II : Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril. In: Journal of Hypertension. 1984 ; Vol. 2, No. 6. pp. 599-604.

Bibtex

@article{7c75a07e8de643b28652267b90f26923,
title = "Cerebrovascular aspects of converting-enzyme inhibition II: Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril",
abstract = "The blood-brain barrier permeability to captopril, and the cerebrovascular effects of intracerebroventricular administration of captopril, were studied in normotensive Wistar rats. The blood-brain barrier permeability-surface area product (PS), determined by an integral-uptake method, was about 1 X 10(-5) cm3/g/s in all brain regions studied. This was three to four times lower than the simultaneously determined PS of Na+ and Cl-, both of which are known to have very low blood-brain barrier permeability. Cerebral blood flow, determined by the intra-arterial 133xenon injection method, was unaffected by intracerebroventricular administration of 100 micrograms captopril. Furthermore the lower limit of cerebral blood flow autoregulation during haemorrhagic hypotension was also unaffected, being in the mean arterial pressure range (50-69 mmHg) in both controls and captopril-treated rats. It was concluded that the blood-brain barrier permeability of captopril was negligible and that inhibition of the brain renin-angiotensin system has no effect on global cerebral blood flow. The cerebrovascular effects of intravenously administered captopril (a resetting to lower pressure of the limits and range of cerebral blood flow autoregulation) are probably exerted via converting enzyme on the luminal surface of cerebral vessels.",
keywords = "Angiotensin-Converting Enzyme Inhibitors, Animals, Autoradiography, Blood Pressure/drug effects, Blood-Brain Barrier, Brain/pathology, Capillary Permeability, Captopril/metabolism, Cerebrovascular Circulation/drug effects, Chlorides/metabolism, Homeostasis, Injections, Intraventricular, Male, Proline/analogs & derivatives, Rats, Rats, Inbred Strains, Sodium/metabolism",
author = "Jarden, {J O} and Barry, {D I} and M Juhler and Graham, {D I} and S Strandgaard and Paulson, {O B}",
year = "1984",
month = dec,
doi = "10.1097/00004872-198412000-00004",
language = "English",
volume = "2",
pages = "599--604",
journal = "Journal of Hypertension, Supplement",
issn = "0952-1178",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Cerebrovascular aspects of converting-enzyme inhibition II

T2 - Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril

AU - Jarden, J O

AU - Barry, D I

AU - Juhler, M

AU - Graham, D I

AU - Strandgaard, S

AU - Paulson, O B

PY - 1984/12

Y1 - 1984/12

N2 - The blood-brain barrier permeability to captopril, and the cerebrovascular effects of intracerebroventricular administration of captopril, were studied in normotensive Wistar rats. The blood-brain barrier permeability-surface area product (PS), determined by an integral-uptake method, was about 1 X 10(-5) cm3/g/s in all brain regions studied. This was three to four times lower than the simultaneously determined PS of Na+ and Cl-, both of which are known to have very low blood-brain barrier permeability. Cerebral blood flow, determined by the intra-arterial 133xenon injection method, was unaffected by intracerebroventricular administration of 100 micrograms captopril. Furthermore the lower limit of cerebral blood flow autoregulation during haemorrhagic hypotension was also unaffected, being in the mean arterial pressure range (50-69 mmHg) in both controls and captopril-treated rats. It was concluded that the blood-brain barrier permeability of captopril was negligible and that inhibition of the brain renin-angiotensin system has no effect on global cerebral blood flow. The cerebrovascular effects of intravenously administered captopril (a resetting to lower pressure of the limits and range of cerebral blood flow autoregulation) are probably exerted via converting enzyme on the luminal surface of cerebral vessels.

AB - The blood-brain barrier permeability to captopril, and the cerebrovascular effects of intracerebroventricular administration of captopril, were studied in normotensive Wistar rats. The blood-brain barrier permeability-surface area product (PS), determined by an integral-uptake method, was about 1 X 10(-5) cm3/g/s in all brain regions studied. This was three to four times lower than the simultaneously determined PS of Na+ and Cl-, both of which are known to have very low blood-brain barrier permeability. Cerebral blood flow, determined by the intra-arterial 133xenon injection method, was unaffected by intracerebroventricular administration of 100 micrograms captopril. Furthermore the lower limit of cerebral blood flow autoregulation during haemorrhagic hypotension was also unaffected, being in the mean arterial pressure range (50-69 mmHg) in both controls and captopril-treated rats. It was concluded that the blood-brain barrier permeability of captopril was negligible and that inhibition of the brain renin-angiotensin system has no effect on global cerebral blood flow. The cerebrovascular effects of intravenously administered captopril (a resetting to lower pressure of the limits and range of cerebral blood flow autoregulation) are probably exerted via converting enzyme on the luminal surface of cerebral vessels.

KW - Angiotensin-Converting Enzyme Inhibitors

KW - Animals

KW - Autoradiography

KW - Blood Pressure/drug effects

KW - Blood-Brain Barrier

KW - Brain/pathology

KW - Capillary Permeability

KW - Captopril/metabolism

KW - Cerebrovascular Circulation/drug effects

KW - Chlorides/metabolism

KW - Homeostasis

KW - Injections, Intraventricular

KW - Male

KW - Proline/analogs & derivatives

KW - Rats

KW - Rats, Inbred Strains

KW - Sodium/metabolism

U2 - 10.1097/00004872-198412000-00004

DO - 10.1097/00004872-198412000-00004

M3 - Journal article

C2 - 6098609

VL - 2

SP - 599

EP - 604

JO - Journal of Hypertension, Supplement

JF - Journal of Hypertension, Supplement

SN - 0952-1178

IS - 6

ER -

ID: 275995183