TY - JOUR

T1 - Cerebrovascular aspects of converting-enzyme inhibition I

T2 - Effects of intravenous captopril in spontaneously hypertensive and normotensive rats

AU - Barry, D I

AU - Jarden, J O

AU - Paulson, O B

AU - Graham, D I

AU - Strandgaard, S

PY - 1984/12

Y1 - 1984/12

N2 - The cerebrovascular effects of converting enzyme inhibition were examined in normotensive and hypertensive rats. Cerebral blood flow was measured using the intracarotid 133xenon injection method in halothane/nitrous oxide anaesthetized animals. The main finding was that following intravenous administration of captopril (10 mg/kg), cerebral blood flow autoregulation was markedly altered. Although cerebral blood flow was unchanged from baseline levels, both the lower and upper limits of autoregulation were reset to lower mean arterial pressure and the autoregulatory plateau shortened. The lower limit was shifted 20-30 mmHg, the upper limit 50-60 mmHg, and the plateau shortened by 20-40 mmHg. The effect was interpreted as being a consequence of compensatory autoregulatory constriction of small resistance vessels in the brain following captopril-induced dilatation of large resistance vessels. It was inferred that locally produced angiotensin II might play a role in the resistance of large cerebral arteries.

AB - The cerebrovascular effects of converting enzyme inhibition were examined in normotensive and hypertensive rats. Cerebral blood flow was measured using the intracarotid 133xenon injection method in halothane/nitrous oxide anaesthetized animals. The main finding was that following intravenous administration of captopril (10 mg/kg), cerebral blood flow autoregulation was markedly altered. Although cerebral blood flow was unchanged from baseline levels, both the lower and upper limits of autoregulation were reset to lower mean arterial pressure and the autoregulatory plateau shortened. The lower limit was shifted 20-30 mmHg, the upper limit 50-60 mmHg, and the plateau shortened by 20-40 mmHg. The effect was interpreted as being a consequence of compensatory autoregulatory constriction of small resistance vessels in the brain following captopril-induced dilatation of large resistance vessels. It was inferred that locally produced angiotensin II might play a role in the resistance of large cerebral arteries.

KW - Angiotensin-Converting Enzyme Inhibitors

KW - Animals

KW - Blood Pressure/drug effects

KW - Captopril/pharmacology

KW - Cerebrovascular Circulation/drug effects

KW - Homeostasis

KW - Hypertension/pathology

KW - Injections, Intravenous

KW - Male

KW - Nervous System/pathology

KW - Proline/analogs & derivatives

KW - Rats

KW - Rats, Inbred SHR

KW - Rats, Inbred WKY

KW - Time Factors

U2 - 10.1097/00004872-198412000-00003

DO - 10.1097/00004872-198412000-00003

M3 - Journal article

C2 - 6098608

VL - 2

SP - 589

EP - 597

JO - Journal of Hypertension, Supplement

JF - Journal of Hypertension, Supplement

SN - 0952-1178

IS - 6

ER -