Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study
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Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis : an exploratory study. / Blinkenberg, Morten; Mathiesen, Henrik K; Tscherning, Thomas; Jønsson, Agnete; Svarer, Claus; Holm, Søren; Sellebjerg, Finn; Paulson, Olaf B; Hanson, Lars G; Sorensen, Per S.
In: Neurological Research, Vol. 34, No. 1, 01.2012, p. 52-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis
T2 - an exploratory study
AU - Blinkenberg, Morten
AU - Mathiesen, Henrik K
AU - Tscherning, Thomas
AU - Jønsson, Agnete
AU - Svarer, Claus
AU - Holm, Søren
AU - Sellebjerg, Finn
AU - Paulson, Olaf B
AU - Hanson, Lars G
AU - Sorensen, Per S
PY - 2012/1
Y1 - 2012/1
N2 - Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability.
AB - Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability.
U2 - 10.1179/1743132811Y.0000000059
DO - 10.1179/1743132811Y.0000000059
M3 - Journal article
VL - 34
SP - 52
EP - 58
JO - Neurological Research
JF - Neurological Research
SN - 0161-6412
IS - 1
ER -
ID: 48525026