Cerebral metabolism in a case of multiple sclerosis with acute mental disorder
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Cerebral metabolism in a case of multiple sclerosis with acute mental disorder. / Blinkenberg, M; Rune, K; Jønsson, A; Holm, S; Jensen, C V; Paulson, O B; Sørensen, P S.
In: Acta Neurologica Scandinavica, Vol. 94, No. 5, 11.1996, p. 310-3.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cerebral metabolism in a case of multiple sclerosis with acute mental disorder
AU - Blinkenberg, M
AU - Rune, K
AU - Jønsson, A
AU - Holm, S
AU - Jensen, C V
AU - Paulson, O B
AU - Sørensen, P S
PY - 1996/11
Y1 - 1996/11
N2 - Acute mental disorder in early Multiple Sclerosis (MS) is rare and little is known about the structural and metabolic changes in this relation. We present an MS patient with discrete motor and sensory deficits, who developed severe behavioral changes over a period of nine months during the initial course of the disease. The cerebral metabolic rate of glucose (CMRglc) was measured using positron emission tomography (PET), and the patient underwent MRI as well as a comprehensive battery of neuropsychological tests. Significantly reduced values of CMRglc were found bilaterally in the frontal and temporal cortex, the putamen, the thalamus and the hippocampus. The MRI revealed progression of MS lesions in the frontal lobes during the development of mental symptoms. Neuropsychological examination showed wide spread cognitive dysfunction, and a pronounced frontal lobe syndrome. The study demonstrates the remote metabolic effects of lesions affecting subcortical neural connections in an MS patient with severe cognitive dysfunction.
AB - Acute mental disorder in early Multiple Sclerosis (MS) is rare and little is known about the structural and metabolic changes in this relation. We present an MS patient with discrete motor and sensory deficits, who developed severe behavioral changes over a period of nine months during the initial course of the disease. The cerebral metabolic rate of glucose (CMRglc) was measured using positron emission tomography (PET), and the patient underwent MRI as well as a comprehensive battery of neuropsychological tests. Significantly reduced values of CMRglc were found bilaterally in the frontal and temporal cortex, the putamen, the thalamus and the hippocampus. The MRI revealed progression of MS lesions in the frontal lobes during the development of mental symptoms. Neuropsychological examination showed wide spread cognitive dysfunction, and a pronounced frontal lobe syndrome. The study demonstrates the remote metabolic effects of lesions affecting subcortical neural connections in an MS patient with severe cognitive dysfunction.
KW - Acute Disease
KW - Adult
KW - Brain/metabolism
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Mental Disorders/diagnostic imaging
KW - Multiple Sclerosis/complications
KW - Neuropsychological Tests
KW - Tomography, Emission-Computed
U2 - 10.1111/j.1600-0404.1996.tb07071.x
DO - 10.1111/j.1600-0404.1996.tb07071.x
M3 - Journal article
C2 - 8947281
VL - 94
SP - 310
EP - 313
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 5
ER -
ID: 274965454