Cerebral Metabolic Rate of Glucose and Cognitive Tests in Long COVID Patients
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Cerebral Metabolic Rate of Glucose and Cognitive Tests in Long COVID Patients. / Miskowiak, Kamilla W.; Bech, Johanne L.; Henriksen, Alexander Cuculiza; Johnsen, Stine; Podlekareva, Daria; Marner, Lisbeth.
In: Brain Sciences, Vol. 13, No. 1, 23, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cerebral Metabolic Rate of Glucose and Cognitive Tests in Long COVID Patients
AU - Miskowiak, Kamilla W.
AU - Bech, Johanne L.
AU - Henriksen, Alexander Cuculiza
AU - Johnsen, Stine
AU - Podlekareva, Daria
AU - Marner, Lisbeth
N1 - Publisher Copyright: © 2022 by the authors.
PY - 2023
Y1 - 2023
N2 - Background: Common long-term sequelae after COVID-19 include fatigue and cognitive impairment. Although symptoms interfere with daily living, the underlying pathology is largely unknown. Previous studies report relative hypometabolism in frontal, limbic and cerebellar regions suggesting focal brain involvement. We aimed to determine whether absolute hypometabolism was present and correlated to same day standardized neurocognitive testing. Methods: Fourteen patients included from a long COVID clinic had cognitive testing and quantitative dynamic [18F]FDG PET of the brain on the same day to correlate cognitive function to metabolic glucose rate. Results: We found no hypometabolism in frontal, limbic and cerebellar regions in cognitively impaired relative to cognitive intact patients. In contrast, the cognitive impaired patients showed higher cerebellar metabolism (p = 0.03), which correlated with more severe deficits in working memory and executive function (p = 0.03). Conclusions: Hypermetabolism in the cerebellum may reflect inefficient brain processing and play a role in cognitive impairments after COVID-19.
AB - Background: Common long-term sequelae after COVID-19 include fatigue and cognitive impairment. Although symptoms interfere with daily living, the underlying pathology is largely unknown. Previous studies report relative hypometabolism in frontal, limbic and cerebellar regions suggesting focal brain involvement. We aimed to determine whether absolute hypometabolism was present and correlated to same day standardized neurocognitive testing. Methods: Fourteen patients included from a long COVID clinic had cognitive testing and quantitative dynamic [18F]FDG PET of the brain on the same day to correlate cognitive function to metabolic glucose rate. Results: We found no hypometabolism in frontal, limbic and cerebellar regions in cognitively impaired relative to cognitive intact patients. In contrast, the cognitive impaired patients showed higher cerebellar metabolism (p = 0.03), which correlated with more severe deficits in working memory and executive function (p = 0.03). Conclusions: Hypermetabolism in the cerebellum may reflect inefficient brain processing and play a role in cognitive impairments after COVID-19.
KW - brain fog
KW - brain metabolism
KW - cognitive impairment
KW - COVID-19
KW - FDG
KW - PET
KW - positron emission tomography
KW - quality of life
KW - work function
U2 - 10.3390/brainsci13010023
DO - 10.3390/brainsci13010023
M3 - Journal article
C2 - 36672005
AN - SCOPUS:85146820003
VL - 13
JO - Brain Sciences
JF - Brain Sciences
SN - 2076-3425
IS - 1
M1 - 23
ER -
ID: 373028752