Cerebral blood flow deficits in hereditary essential myoclonus
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Hereditary essential myoclonus is a disease in which segmental myoclonus is the sole clinical abnormality and whose cause is unknown. It is characterized by an early onset, a benign course, an autosomal dominant pattern of inheritance, the absence of any other neurologic dysfunction, and normal results of auxiliary tests. Cerebral blood flow studies of a father and son with this disease showed a cortical blood flow reduction contralateral to the myoclonus symptoms. We postulate the cause to be a focal unilateral subcortical cerebral lesion, either in the basal ganglia or in the brain stem, with subsequent cortical deafferentation.
Original language | English |
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Journal | Archives of Neurology |
Volume | 49 |
Issue number | 2 |
Pages (from-to) | 179-82 |
Number of pages | 4 |
ISSN | 0003-9942 |
DOIs | |
Publication status | Published - Feb 1992 |
- Adult, Brain/diagnostic imaging, Cerebrovascular Circulation, Child, Humans, Male, Myoclonus/genetics, Tomography, Emission-Computed, Single-Photon
Research areas
ID: 274927414