Cell-associated HIV DNA measured early during infection has prognostic value independent of serum HIV RNA measured concomitantly

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cell-associated HIV DNA measured early during infection has prognostic value independent of serum HIV RNA measured concomitantly. / Katzenstein, Terese L; Oliveri, Roberto S; Benfield, Thomas; Eugen-Olsen, Jesper; Nielsen, Claus; Gerstoft, Jan; Copenhagen AIDS Cohort Study Group.

In: Scandinavian Journal of Infectious Diseases, Vol. 34, No. 7, 2002, p. 529-33.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Katzenstein, TL, Oliveri, RS, Benfield, T, Eugen-Olsen, J, Nielsen, C, Gerstoft, J & Copenhagen AIDS Cohort Study Group 2002, 'Cell-associated HIV DNA measured early during infection has prognostic value independent of serum HIV RNA measured concomitantly', Scandinavian Journal of Infectious Diseases, vol. 34, no. 7, pp. 529-33. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12195879&itool=iconabstr&query_hl=1&itool=pubmed_docsum>

APA

Katzenstein, T. L., Oliveri, R. S., Benfield, T., Eugen-Olsen, J., Nielsen, C., Gerstoft, J., & Copenhagen AIDS Cohort Study Group (2002). Cell-associated HIV DNA measured early during infection has prognostic value independent of serum HIV RNA measured concomitantly. Scandinavian Journal of Infectious Diseases, 34(7), 529-33. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12195879&itool=iconabstr&query_hl=1&itool=pubmed_docsum

Vancouver

Katzenstein TL, Oliveri RS, Benfield T, Eugen-Olsen J, Nielsen C, Gerstoft J et al. Cell-associated HIV DNA measured early during infection has prognostic value independent of serum HIV RNA measured concomitantly. Scandinavian Journal of Infectious Diseases. 2002;34(7):529-33.

Author

Katzenstein, Terese L ; Oliveri, Roberto S ; Benfield, Thomas ; Eugen-Olsen, Jesper ; Nielsen, Claus ; Gerstoft, Jan ; Copenhagen AIDS Cohort Study Group. / Cell-associated HIV DNA measured early during infection has prognostic value independent of serum HIV RNA measured concomitantly. In: Scandinavian Journal of Infectious Diseases. 2002 ; Vol. 34, No. 7. pp. 529-33.

Bibtex

@article{0ac7000febf04cf6b770c8c138eadca9,
title = "Cell-associated HIV DNA measured early during infection has prognostic value independent of serum HIV RNA measured concomitantly",
abstract = "Using data from the Danish AIDS Cohort of HIV-infected homosexual men established in the 1980s, the prognostic value of early HIV DNA loads was evaluated. In addition to DNA measurements, concomitant serum HIV RNA levels, CD4 cell counts and CCR5 genotypes were determined. The patients were divided into 3 groups, according to whether their cell-associated HIV DNA load was < or = 100, 500 or > or = 2,500 DNA copies/10(6) peripheral blood mononuclear cells. Clinical progression rates differed significantly between the groups (p < 0.005). Cell-associated HIV DNA load had prognostic value independent of serum HIV RNA (p < 0.02). However, when HIV DNA, HIV RNA and CD4 cell counts were all included in a Cox model, only serum HIV RNA had independent prognostic value. Patients heterozygous for the CCR5 delta 32 allele had significantly lower HIV DNA loads than those homozygous for the normal allele (p < 0.05). The interplay between HIV RNA and DNA levels is discussed, together with the possibility that cell-associated HIV DNA load is a marker of the HIV RNA peak seen shortly after primary HIV infection.",
author = "Katzenstein, {Terese L} and Oliveri, {Roberto S} and Thomas Benfield and Jesper Eugen-Olsen and Claus Nielsen and Jan Gerstoft and Jan Gerstoft",
year = "2002",
language = "English",
volume = "34",
pages = "529--33",
journal = "Infectious Diseases",
issn = "2374-4235",
publisher = "Taylor & Francis",
number = "7",

}

RIS

TY - JOUR

T1 - Cell-associated HIV DNA measured early during infection has prognostic value independent of serum HIV RNA measured concomitantly

AU - Katzenstein, Terese L

AU - Oliveri, Roberto S

AU - Benfield, Thomas

AU - Eugen-Olsen, Jesper

AU - Nielsen, Claus

AU - Gerstoft, Jan

AU - Copenhagen AIDS Cohort Study Group

PY - 2002

Y1 - 2002

N2 - Using data from the Danish AIDS Cohort of HIV-infected homosexual men established in the 1980s, the prognostic value of early HIV DNA loads was evaluated. In addition to DNA measurements, concomitant serum HIV RNA levels, CD4 cell counts and CCR5 genotypes were determined. The patients were divided into 3 groups, according to whether their cell-associated HIV DNA load was < or = 100, 500 or > or = 2,500 DNA copies/10(6) peripheral blood mononuclear cells. Clinical progression rates differed significantly between the groups (p < 0.005). Cell-associated HIV DNA load had prognostic value independent of serum HIV RNA (p < 0.02). However, when HIV DNA, HIV RNA and CD4 cell counts were all included in a Cox model, only serum HIV RNA had independent prognostic value. Patients heterozygous for the CCR5 delta 32 allele had significantly lower HIV DNA loads than those homozygous for the normal allele (p < 0.05). The interplay between HIV RNA and DNA levels is discussed, together with the possibility that cell-associated HIV DNA load is a marker of the HIV RNA peak seen shortly after primary HIV infection.

AB - Using data from the Danish AIDS Cohort of HIV-infected homosexual men established in the 1980s, the prognostic value of early HIV DNA loads was evaluated. In addition to DNA measurements, concomitant serum HIV RNA levels, CD4 cell counts and CCR5 genotypes were determined. The patients were divided into 3 groups, according to whether their cell-associated HIV DNA load was < or = 100, 500 or > or = 2,500 DNA copies/10(6) peripheral blood mononuclear cells. Clinical progression rates differed significantly between the groups (p < 0.005). Cell-associated HIV DNA load had prognostic value independent of serum HIV RNA (p < 0.02). However, when HIV DNA, HIV RNA and CD4 cell counts were all included in a Cox model, only serum HIV RNA had independent prognostic value. Patients heterozygous for the CCR5 delta 32 allele had significantly lower HIV DNA loads than those homozygous for the normal allele (p < 0.05). The interplay between HIV RNA and DNA levels is discussed, together with the possibility that cell-associated HIV DNA load is a marker of the HIV RNA peak seen shortly after primary HIV infection.

M3 - Journal article

VL - 34

SP - 529

EP - 533

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 7

ER -

ID: 34171386