CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus. / Bassi, Maria R; Kongsgaard, Michael; Steffensen, Maria A; Fenger, Christina; Rasmussen, Michael; Skjødt, Karsten; Finsen, Bente; Buus, Anette Stryhn; Buus, Søren; Christensen, Jan P; Thomsen, Allan Randrup.

In: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, No. 3, 01.02.2015, p. 1141-53.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bassi, MR, Kongsgaard, M, Steffensen, MA, Fenger, C, Rasmussen, M, Skjødt, K, Finsen, B, Buus, AS, Buus, S, Christensen, JP & Thomsen, AR 2015, 'CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus', Journal of immunology (Baltimore, Md. : 1950), vol. 194, no. 3, pp. 1141-53. https://doi.org/10.4049/jimmunol.1402605

APA

Bassi, M. R., Kongsgaard, M., Steffensen, M. A., Fenger, C., Rasmussen, M., Skjødt, K., Finsen, B., Buus, A. S., Buus, S., Christensen, J. P., & Thomsen, A. R. (2015). CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus. Journal of immunology (Baltimore, Md. : 1950), 194(3), 1141-53. https://doi.org/10.4049/jimmunol.1402605

Vancouver

Bassi MR, Kongsgaard M, Steffensen MA, Fenger C, Rasmussen M, Skjødt K et al. CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus. Journal of immunology (Baltimore, Md. : 1950). 2015 Feb 1;194(3):1141-53. https://doi.org/10.4049/jimmunol.1402605

Author

Bassi, Maria R ; Kongsgaard, Michael ; Steffensen, Maria A ; Fenger, Christina ; Rasmussen, Michael ; Skjødt, Karsten ; Finsen, Bente ; Buus, Anette Stryhn ; Buus, Søren ; Christensen, Jan P ; Thomsen, Allan Randrup. / CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus. In: Journal of immunology (Baltimore, Md. : 1950). 2015 ; Vol. 194, No. 3. pp. 1141-53.

Bibtex

@article{c83052d232d746978298b970381ea112,
title = "CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus",
abstract = "The attenuated yellow fever (YF) vaccine (YF-17D) was developed in the 1930s, yet little is known about the protective mechanisms underlying its efficiency. In this study, we analyzed the relative contribution of cell-mediated and humoral immunity to the vaccine-induced protection in a murine model of YF-17D infection. Using different strains of knockout mice, we found that CD4(+) T cells, B cells, and Abs are required for full clinical protection of vaccinated mice, whereas CD8(+) T cells are dispensable for long-term survival after intracerebral challenge. However, by analyzing the immune response inside the infected CNS, we observed an accelerated T cell influx into the brain after intracerebral challenge of vaccinated mice, and this T cell recruitment correlated with improved virus control in the brain. Using mice deficient in B cells we found that, in the absence of Abs, YF vaccination can still induce some antiviral protection, and in vivo depletion of CD8(+) T cells from these animals revealed a pivotal role for CD8(+) T cells in controlling virus replication in the absence of a humoral response. Finally, we demonstrated that effector CD8(+) T cells also contribute to viral control in the presence of circulating YF-specific Abs. To our knowledge, this is the first time that YF-specific CD8(+) T cells have been demonstrated to possess antiviral activity in vivo.",
author = "Bassi, {Maria R} and Michael Kongsgaard and Steffensen, {Maria A} and Christina Fenger and Michael Rasmussen and Karsten Skj{\o}dt and Bente Finsen and Buus, {Anette Stryhn} and S{\o}ren Buus and Christensen, {Jan P} and Thomsen, {Allan Randrup}",
note = "Copyright {\textcopyright} 2014 by The American Association of Immunologists, Inc.",
year = "2015",
month = feb,
day = "1",
doi = "10.4049/jimmunol.1402605",
language = "English",
volume = "194",
pages = "1141--53",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "3",

}

RIS

TY - JOUR

T1 - CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus

AU - Bassi, Maria R

AU - Kongsgaard, Michael

AU - Steffensen, Maria A

AU - Fenger, Christina

AU - Rasmussen, Michael

AU - Skjødt, Karsten

AU - Finsen, Bente

AU - Buus, Anette Stryhn

AU - Buus, Søren

AU - Christensen, Jan P

AU - Thomsen, Allan Randrup

N1 - Copyright © 2014 by The American Association of Immunologists, Inc.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - The attenuated yellow fever (YF) vaccine (YF-17D) was developed in the 1930s, yet little is known about the protective mechanisms underlying its efficiency. In this study, we analyzed the relative contribution of cell-mediated and humoral immunity to the vaccine-induced protection in a murine model of YF-17D infection. Using different strains of knockout mice, we found that CD4(+) T cells, B cells, and Abs are required for full clinical protection of vaccinated mice, whereas CD8(+) T cells are dispensable for long-term survival after intracerebral challenge. However, by analyzing the immune response inside the infected CNS, we observed an accelerated T cell influx into the brain after intracerebral challenge of vaccinated mice, and this T cell recruitment correlated with improved virus control in the brain. Using mice deficient in B cells we found that, in the absence of Abs, YF vaccination can still induce some antiviral protection, and in vivo depletion of CD8(+) T cells from these animals revealed a pivotal role for CD8(+) T cells in controlling virus replication in the absence of a humoral response. Finally, we demonstrated that effector CD8(+) T cells also contribute to viral control in the presence of circulating YF-specific Abs. To our knowledge, this is the first time that YF-specific CD8(+) T cells have been demonstrated to possess antiviral activity in vivo.

AB - The attenuated yellow fever (YF) vaccine (YF-17D) was developed in the 1930s, yet little is known about the protective mechanisms underlying its efficiency. In this study, we analyzed the relative contribution of cell-mediated and humoral immunity to the vaccine-induced protection in a murine model of YF-17D infection. Using different strains of knockout mice, we found that CD4(+) T cells, B cells, and Abs are required for full clinical protection of vaccinated mice, whereas CD8(+) T cells are dispensable for long-term survival after intracerebral challenge. However, by analyzing the immune response inside the infected CNS, we observed an accelerated T cell influx into the brain after intracerebral challenge of vaccinated mice, and this T cell recruitment correlated with improved virus control in the brain. Using mice deficient in B cells we found that, in the absence of Abs, YF vaccination can still induce some antiviral protection, and in vivo depletion of CD8(+) T cells from these animals revealed a pivotal role for CD8(+) T cells in controlling virus replication in the absence of a humoral response. Finally, we demonstrated that effector CD8(+) T cells also contribute to viral control in the presence of circulating YF-specific Abs. To our knowledge, this is the first time that YF-specific CD8(+) T cells have been demonstrated to possess antiviral activity in vivo.

U2 - 10.4049/jimmunol.1402605

DO - 10.4049/jimmunol.1402605

M3 - Journal article

C2 - 25539816

VL - 194

SP - 1141

EP - 1153

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 3

ER -

ID: 129601786