CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene
Research output: Contribution to journal › Journal article › Research › peer-review
An attempt was made to identify the selection pressures put upon a growing tumour by CD8+ T cells. To this end tumours induced with 3-methylcholanthrene in T cell-deficient nude mice and in congenic T cell-competent nu/+ mice were transplanted to nu/+ recipients. The rejection rate of the sarcomas from nude mice was almost twice that of the sarcomas from nu/+ mice. Depletion of CD8+ T cells from nu/+ recipients prior to transplantation made them accept nude tumours that were consistently rejected by untreated nu/+ recipients. These findings suggest that a methylcholanthrene sarcoma during its growth in a T cell-competent host adapts to the T cell system through a selective elimination of highly immunogenic tumour cells that are susceptible to CD8+ T cell-mediated lysis.
Original language | English |
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Journal | Clinical and Experimental Immunology |
Volume | 121 |
Issue number | 2 |
Pages (from-to) | 210-5 |
Number of pages | 5 |
ISSN | 0009-9104 |
Publication status | Published - 2000 |
Bibliographical note
Keywords: Animals; CD8-Positive T-Lymphocytes; Carcinogens; Female; Fibrosarcoma; Graft Rejection; Heterozygote; Immunologic Surveillance; Methylcholanthrene; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Sarcoma, Experimental
ID: 9701527