Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
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- Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
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CONTEXT: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.
OBJECTIVES: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.
DESIGN: Bi-directional Mendelian randomization (MR) analysis on prospective cohorts.
SETTING: Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).
PARTICIPANTS: 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.
MAIN OUTCOME MEASURES: BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.
RESULTS: 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349).
CONCLUSIONS: Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men.
Original language | English |
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Article number | e0176277 |
Journal | PloS one |
Volume | 12 |
Issue number | 4 |
Number of pages | 15 |
ISSN | 1932-6203 |
DOIs | |
Publication status | Published - 2017 |
- Adolescent, Adult, Aged, Body Mass Index, Genetic Predisposition to Disease, Humans, Male, Mendelian Randomization Analysis, Obesity, Phenotype, Polymorphism, Single Nucleotide, Testosterone, Young Adult, Journal Article
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