Breast Cancer Histopathology in the Age of Molecular Oncology
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Breast Cancer Histopathology in the Age of Molecular Oncology. / Kos, Zuzana; Nielsen, Torsten O.; Laenkholm, Anne Vibeke.
In: Cold Spring Harbor Perspectives in Medicine, Vol. 14, No. 6, 2024.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Breast Cancer Histopathology in the Age of Molecular Oncology
AU - Kos, Zuzana
AU - Nielsen, Torsten O.
AU - Laenkholm, Anne Vibeke
N1 - Publisher Copyright: Copyright © 2024 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2024
Y1 - 2024
N2 - For more than a century, microscopic histology has been the cornerstone for cancer diagnosis, and breast carcinoma is no exception. In recent years, clinical biomarkers, gene expression profiles, and other molecular tests have shown increasing utility for identifying the key biological features that guide prognosis and treatment of breast cancer. Indeed, the most common histologic pattern-invasive ductal carcinoma of no special type-provides relatively little guidance to management beyond triggering grading, biomarker testing, and clinical staging. However, many less common histologic patterns can be recognized by trained pathologists, which in many cases can be linked to characteristic biomarker and gene expression patterns, underlying mutations, prognosis, and therapy. Herein we describe more than a dozen such histomorphologic subtypes (including lobular, metaplastic, salivary analog, and several good prognosis special types of breast cancer) in the context of their molecular and clinical features.
AB - For more than a century, microscopic histology has been the cornerstone for cancer diagnosis, and breast carcinoma is no exception. In recent years, clinical biomarkers, gene expression profiles, and other molecular tests have shown increasing utility for identifying the key biological features that guide prognosis and treatment of breast cancer. Indeed, the most common histologic pattern-invasive ductal carcinoma of no special type-provides relatively little guidance to management beyond triggering grading, biomarker testing, and clinical staging. However, many less common histologic patterns can be recognized by trained pathologists, which in many cases can be linked to characteristic biomarker and gene expression patterns, underlying mutations, prognosis, and therapy. Herein we describe more than a dozen such histomorphologic subtypes (including lobular, metaplastic, salivary analog, and several good prognosis special types of breast cancer) in the context of their molecular and clinical features.
U2 - 10.1101/cshperspect.a041647
DO - 10.1101/cshperspect.a041647
M3 - Review
C2 - 38151327
AN - SCOPUS:85195228612
VL - 14
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
SN - 2157-1422
IS - 6
ER -
ID: 394433607