Brain marker protein changes after short- and long-term ethanol intoxication and withdrawal in the rat.
Research output: Contribution to journal › Journal article › Research › peer-review
The brain marker proteins, D1, D2, and D3, localised to neuronal membranes, and mitochondrial and cytoplasmic marker proteins (MM and CM), were studied during 1-6 days (short term) intragastrically-induced severe ethanol intoxication and during 1 month (long-term) ethanol intoxication established by a liquid diet regimen. The concentrations of the same brain proteins were also measured during withdrawal from the ethanol intoxication periods. Three categories of effect were encountered: decreased concentration of brain marker proteins during severe short-term intoxication the effect being most marked for D3, possibly indicating degradation of mature synapses; increased concentration of proteins D2 and MM during withdrawal, the D2 changes possibly indicating formation of new synapses; increased concentration of D1 protein and MM during long-term intoxication. We suggest that the changes in brain marker proteins reflect dynamic changes of subcellular neuronal structures which may form a part of the basis of functional tolerance to and physical dependence upon ethanol or the reversion of these states after withdrawal of ethanol.
Original language | English |
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Journal | Journal of Psychiatric Research |
Volume | 21 |
Issue number | 2 |
Pages (from-to) | 171-83 |
Number of pages | 12 |
ISSN | 0022-3956 |
Publication status | Published - 1987 |
Bibliographical note
Keywords: Alcohol Withdrawal Delirium; Alcoholic Intoxication; Alcoholism; Animals; Brain; Cytoplasm; Male; Mitochondria; Nerve Tissue Proteins; Psychoses, Alcoholic; Rats; Rats, Inbred Strains
ID: 5941424