Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure
Research output: Contribution to journal › Journal article › Research › peer-review
The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations. In this study we hypothesize that the cerebral concentrations of hypoxanthine, inosine, and lactate/pyruvate (LP) ratio are increased and correlated in patients with acute liver failure. Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively).
Original language | English |
---|---|
Journal | Journal of Hepatology |
Volume | 53 |
Issue number | 6 |
Pages (from-to) | 1054-8 |
Number of pages | 5 |
ISSN | 0168-8278 |
DOIs | |
Publication status | Published - 1 Dec 2010 |
ID: 34074302