Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure
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Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. / Bjerring, Peter Nissen; Hauerberg, John; Jørgensen, Linda; Frederiksen, Hans-Jørgen; Tofteng, Flemming; Hansen, Bent Adel; Larsen, Fin Stolze.
In: Journal of Hepatology, Vol. 53, No. 6, 01.12.2010, p. 1054-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure
AU - Bjerring, Peter Nissen
AU - Hauerberg, John
AU - Jørgensen, Linda
AU - Frederiksen, Hans-Jørgen
AU - Tofteng, Flemming
AU - Hansen, Bent Adel
AU - Larsen, Fin Stolze
N1 - Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations. In this study we hypothesize that the cerebral concentrations of hypoxanthine, inosine, and lactate/pyruvate (LP) ratio are increased and correlated in patients with acute liver failure. Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively).
AB - The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations. In this study we hypothesize that the cerebral concentrations of hypoxanthine, inosine, and lactate/pyruvate (LP) ratio are increased and correlated in patients with acute liver failure. Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively).
U2 - http://dx.doi.org/10.1016/j.jhep.2010.05.032
DO - http://dx.doi.org/10.1016/j.jhep.2010.05.032
M3 - Journal article
VL - 53
SP - 1054
EP - 1058
JO - Journal of Hepatology, Supplement
JF - Journal of Hepatology, Supplement
SN - 0169-5185
IS - 6
ER -
ID: 34074302