Brachyspira murdochii colitis in pigs
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Brachyspira murdochii colitis in pigs. / Jensen, T. K.
In: Veterinary Pathology, Vol. 47, No. 2, 2010, p. 334-338.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Brachyspira murdochii colitis in pigs
AU - Jensen, T. K.
PY - 2010
Y1 - 2010
N2 - The weakly beta-hemolytic porcine spirochete Brachyspira murdochii is considered a normal intestinal commensal. In the present study, however, a field case of B murdochii-associated catarrhal colitis was identified in a pig, as characterized by extensive spirochetal colonization of the surface epithelium. Experimentally, 8 weaned pigs were challenged with the B murdochii isolate, reproducing catarrhal colitis in 2 animals. By applying fluorescent in situ hybridization using a species-specific oligonucleotide probe targeting 23S rRNA, B murdochii organisms were found in high numbers and were closely associated with the surface epithelium in the pigs with catarrhal colitis. The results indicate that, when present in high numbers, B murdochii is low pathogenic for pigs.
AB - The weakly beta-hemolytic porcine spirochete Brachyspira murdochii is considered a normal intestinal commensal. In the present study, however, a field case of B murdochii-associated catarrhal colitis was identified in a pig, as characterized by extensive spirochetal colonization of the surface epithelium. Experimentally, 8 weaned pigs were challenged with the B murdochii isolate, reproducing catarrhal colitis in 2 animals. By applying fluorescent in situ hybridization using a species-specific oligonucleotide probe targeting 23S rRNA, B murdochii organisms were found in high numbers and were closely associated with the surface epithelium in the pigs with catarrhal colitis. The results indicate that, when present in high numbers, B murdochii is low pathogenic for pigs.
KW - Brachyspira murdochii
KW - Colitis
KW - Infection trial
KW - Swine
UR - http://www.scopus.com/inward/record.url?scp=77953986651&partnerID=8YFLogxK
U2 - 10.1177/0300985809359054
DO - 10.1177/0300985809359054
M3 - Journal article
C2 - 20173181
AN - SCOPUS:77953986651
VL - 47
SP - 334
EP - 338
JO - Veterinary Pathology
JF - Veterinary Pathology
SN - 0300-9858
IS - 2
ER -
ID: 339899306