Bone microarchitecture and bone mineral density in multiple sclerosis
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Bone microarchitecture and bone mineral density in multiple sclerosis. / Olsson, A.; Oturai, A.B.; Søndergaard, H. B.; Sellebjerg, F.; Oturai, P. S.
In: Acta Neurologica Scandinavica, Vol. 137, No. 3, 2018, p. 363-369.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Bone microarchitecture and bone mineral density in multiple sclerosis
AU - Olsson, A.
AU - Oturai, A.B.
AU - Søndergaard, H. B.
AU - Sellebjerg, F.
AU - Oturai, P. S.
N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Multiple sclerosis (MS) patients are at increased risk of reduced bone mineral density (BMD) and fractures. The aetiology of bone loss in MS is unclear. Trabecular bone score (TBS) is a novel analytical tool that provides a measurement of the bone microarchitecture. Decreased TBS predicts increased fracture risk independently of BMD. To date, no studies have investigated TBS in MS patients.OBJECTIVES: To assess bone quality in MS patients by TBS and to evaluate potential risk factors that may affect BMD and TBS in patients with MS.METHODS: Two hundred sixty MS patients were included. TBS was calculated using TBS iNsight software (MediMaps® ). Multivariable regression analyses were performed with information on smoking, alcohol, glucocorticoid (GC) treatment, sun exposure, physical activity, vitamin D and BMI.RESULTS: Trabecular bone score was not significantly different from an age-matched reference population. Low TBS was associated with high age (P = .014) and smoking (P = .03). Smoking and physical inactivity were associated with low BMD in spine (P = .034, P = .032). GC treatment was not associated with TBS.CONCLUSION: We could not find altered TBS values among MS patients, suggesting that BMD alone, and not the bone microarchitecture, is affected in MS. However, larger studies are needed to verify these findings and to establish the role of TBS in MS. As in the background population, physical activity and non-smoking habits are associated with better bone health in MS.
AB - BACKGROUND: Multiple sclerosis (MS) patients are at increased risk of reduced bone mineral density (BMD) and fractures. The aetiology of bone loss in MS is unclear. Trabecular bone score (TBS) is a novel analytical tool that provides a measurement of the bone microarchitecture. Decreased TBS predicts increased fracture risk independently of BMD. To date, no studies have investigated TBS in MS patients.OBJECTIVES: To assess bone quality in MS patients by TBS and to evaluate potential risk factors that may affect BMD and TBS in patients with MS.METHODS: Two hundred sixty MS patients were included. TBS was calculated using TBS iNsight software (MediMaps® ). Multivariable regression analyses were performed with information on smoking, alcohol, glucocorticoid (GC) treatment, sun exposure, physical activity, vitamin D and BMI.RESULTS: Trabecular bone score was not significantly different from an age-matched reference population. Low TBS was associated with high age (P = .014) and smoking (P = .03). Smoking and physical inactivity were associated with low BMD in spine (P = .034, P = .032). GC treatment was not associated with TBS.CONCLUSION: We could not find altered TBS values among MS patients, suggesting that BMD alone, and not the bone microarchitecture, is affected in MS. However, larger studies are needed to verify these findings and to establish the role of TBS in MS. As in the background population, physical activity and non-smoking habits are associated with better bone health in MS.
KW - Absorptiometry, Photon
KW - Adult
KW - Aged
KW - Bone Density
KW - Bone and Bones/pathology
KW - Female
KW - Humans
KW - Image Interpretation, Computer-Assisted/methods
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis/pathology
KW - Regression Analysis
KW - Risk Factors
U2 - 10.1111/ane.12884
DO - 10.1111/ane.12884
M3 - Journal article
C2 - 29270986
VL - 137
SP - 363
EP - 369
JO - Acta Neurologica Scandinavica, Supplement
JF - Acta Neurologica Scandinavica, Supplement
SN - 0065-1427
IS - 3
ER -
ID: 215137846