Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells
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Accepted author manuscript, 2.31 MB, PDF document
Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases.
Original language | English |
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Journal | Journal of Bone and Mineral Research |
Volume | 36 |
Issue number | 1 |
Pages (from-to) | 12-23 |
ISSN | 0884-0431 |
DOIs | |
Publication status | Published - 2021 |
- CIRCULATING OSTEOGENIC PRECURSOR CELLS, COP CELLS, FRACTURE, FRAILTY, HETEROTOPIC OSSIFICATION, OSTEOPOROSIS, VASCULAR CALCIFICATION
Research areas
ID: 252677175