Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat

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Standard

Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. / Juhler, M; Barry, D I; Offner, H; Konat, G; Klinken, Leif; Paulson, O B.

In: Brain Research, Vol. 302, No. 2, 08.06.1984, p. 347-55.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Juhler, M, Barry, DI, Offner, H, Konat, G, Klinken, L & Paulson, OB 1984, 'Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat', Brain Research, vol. 302, no. 2, pp. 347-55. https://doi.org/10.1016/0006-8993(84)90249-x

APA

Juhler, M., Barry, D. I., Offner, H., Konat, G., Klinken, L., & Paulson, O. B. (1984). Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. Brain Research, 302(2), 347-55. https://doi.org/10.1016/0006-8993(84)90249-x

Vancouver

Juhler M, Barry DI, Offner H, Konat G, Klinken L, Paulson OB. Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. Brain Research. 1984 Jun 8;302(2):347-55. https://doi.org/10.1016/0006-8993(84)90249-x

Author

Juhler, M ; Barry, D I ; Offner, H ; Konat, G ; Klinken, Leif ; Paulson, O B. / Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. In: Brain Research. 1984 ; Vol. 302, No. 2. pp. 347-55.

Bibtex

@article{6991622cff714fe4ac5a98d877a1796c,
title = "Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat",
abstract = "Experimental allergic encephalomyelitis (EAE) was induced in young male Lewis rats. Blood-brain barrier permeability to radiotracers of different molecular sizes was studied at intervals after induction using a tissue sampling technique. The results were correlated to the clinical picture and to the histological appearance of the central nervous system. Significant increase in blood-brain barrier permeability to small molecules was found to precede clinical symptoms by one day in the lumbar spinal cord and to coincide with the onset of clinical disease in other regions. In all regions, increased blood-brain barrier permeability preceded the occurrence of histological lesions (perivascular cellular infiltrates). No permeability increase to large molecules could be demonstrated.",
keywords = "Animals, Blood-Brain Barrier, Brain/pathology, Capillary Permeability, Chlorides/metabolism, Encephalomyelitis, Autoimmune, Experimental/metabolism, Inulin/metabolism, Male, Myelin Proteins/metabolism, Nerve Fibers, Myelinated/ultrastructure, Rats, Rats, Inbred Lew, Sodium/metabolism, Spinal Cord/metabolism, Sucrose/metabolism",
author = "M Juhler and Barry, {D I} and H Offner and G Konat and Leif Klinken and Paulson, {O B}",
year = "1984",
month = jun,
day = "8",
doi = "10.1016/0006-8993(84)90249-x",
language = "English",
volume = "302",
pages = "347--55",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat

AU - Juhler, M

AU - Barry, D I

AU - Offner, H

AU - Konat, G

AU - Klinken, Leif

AU - Paulson, O B

PY - 1984/6/8

Y1 - 1984/6/8

N2 - Experimental allergic encephalomyelitis (EAE) was induced in young male Lewis rats. Blood-brain barrier permeability to radiotracers of different molecular sizes was studied at intervals after induction using a tissue sampling technique. The results were correlated to the clinical picture and to the histological appearance of the central nervous system. Significant increase in blood-brain barrier permeability to small molecules was found to precede clinical symptoms by one day in the lumbar spinal cord and to coincide with the onset of clinical disease in other regions. In all regions, increased blood-brain barrier permeability preceded the occurrence of histological lesions (perivascular cellular infiltrates). No permeability increase to large molecules could be demonstrated.

AB - Experimental allergic encephalomyelitis (EAE) was induced in young male Lewis rats. Blood-brain barrier permeability to radiotracers of different molecular sizes was studied at intervals after induction using a tissue sampling technique. The results were correlated to the clinical picture and to the histological appearance of the central nervous system. Significant increase in blood-brain barrier permeability to small molecules was found to precede clinical symptoms by one day in the lumbar spinal cord and to coincide with the onset of clinical disease in other regions. In all regions, increased blood-brain barrier permeability preceded the occurrence of histological lesions (perivascular cellular infiltrates). No permeability increase to large molecules could be demonstrated.

KW - Animals

KW - Blood-Brain Barrier

KW - Brain/pathology

KW - Capillary Permeability

KW - Chlorides/metabolism

KW - Encephalomyelitis, Autoimmune, Experimental/metabolism

KW - Inulin/metabolism

KW - Male

KW - Myelin Proteins/metabolism

KW - Nerve Fibers, Myelinated/ultrastructure

KW - Rats

KW - Rats, Inbred Lew

KW - Sodium/metabolism

KW - Spinal Cord/metabolism

KW - Sucrose/metabolism

U2 - 10.1016/0006-8993(84)90249-x

DO - 10.1016/0006-8993(84)90249-x

M3 - Journal article

C2 - 6610460

VL - 302

SP - 347

EP - 355

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

ID: 279595011