Blood flow and microdialysis in the human femoral head

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Blood flow and microdialysis in the human femoral head. / Bøgehøj, Morten; Emmeluth, Claus; Overgaard, Søren.

In: Acta Orthopaedica (Print Edition), Vol. 78, No. 1, 01.02.2007, p. 56-62.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bøgehøj, M, Emmeluth, C & Overgaard, S 2007, 'Blood flow and microdialysis in the human femoral head', Acta Orthopaedica (Print Edition), vol. 78, no. 1, pp. 56-62. https://doi.org/10.1080/17453670610013420

APA

Bøgehøj, M., Emmeluth, C., & Overgaard, S. (2007). Blood flow and microdialysis in the human femoral head. Acta Orthopaedica (Print Edition), 78(1), 56-62. https://doi.org/10.1080/17453670610013420

Vancouver

Bøgehøj M, Emmeluth C, Overgaard S. Blood flow and microdialysis in the human femoral head. Acta Orthopaedica (Print Edition). 2007 Feb 1;78(1):56-62. https://doi.org/10.1080/17453670610013420

Author

Bøgehøj, Morten ; Emmeluth, Claus ; Overgaard, Søren. / Blood flow and microdialysis in the human femoral head. In: Acta Orthopaedica (Print Edition). 2007 ; Vol. 78, No. 1. pp. 56-62.

Bibtex

@article{bfeaceaa47cc47bd934d44ca34788506,
title = "Blood flow and microdialysis in the human femoral head",
abstract = "BACKGROUND: If it would be possible to detect lack of flow and/or the development of ischemia in bone, we might have a way of predicting whether a broken bone will heal. We established microdialysis (MD) and laser Doppler (LD) flow measurement in the human femoral head in order to be able to detect ischemia and measure changes in blood flow. MATERIAL AND METHODS: In 9 patients undergoing total hip arthroplasty for primary osteoarthrosis, two MD catheters were inserted into the femoral head through two drill holes after the blood flow had been visualized by LD. Then primary samples were collected with the femoral head in situ; thereafter, the head was removed and samples were collected over the following 4 hours ex vivo. The variables obtained by MD were concentrations of glucose, lactate, pyruvate, and glycerol in extracellular fluid. RESULTS: The results showed development of ischemia with a statistically significant decrease in glucose concentration and elevation of the lactate/pyruvate ratio over time. The LD showed flow with the femoral head in situ and lack of flow when the femoral head was removed. INTERPRETATION: The use of MD was established in the human femoral head. Ischemic levels were detected within 2 h of cessation of blood flow in most patients.",
author = "Morten B{\o}geh{\o}j and Claus Emmeluth and S{\o}ren Overgaard",
year = "2007",
month = feb,
day = "1",
doi = "10.1080/17453670610013420",
language = "English",
volume = "78",
pages = "56--62",
journal = "Acta Orthopaedica",
issn = "1745-3674",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Blood flow and microdialysis in the human femoral head

AU - Bøgehøj, Morten

AU - Emmeluth, Claus

AU - Overgaard, Søren

PY - 2007/2/1

Y1 - 2007/2/1

N2 - BACKGROUND: If it would be possible to detect lack of flow and/or the development of ischemia in bone, we might have a way of predicting whether a broken bone will heal. We established microdialysis (MD) and laser Doppler (LD) flow measurement in the human femoral head in order to be able to detect ischemia and measure changes in blood flow. MATERIAL AND METHODS: In 9 patients undergoing total hip arthroplasty for primary osteoarthrosis, two MD catheters were inserted into the femoral head through two drill holes after the blood flow had been visualized by LD. Then primary samples were collected with the femoral head in situ; thereafter, the head was removed and samples were collected over the following 4 hours ex vivo. The variables obtained by MD were concentrations of glucose, lactate, pyruvate, and glycerol in extracellular fluid. RESULTS: The results showed development of ischemia with a statistically significant decrease in glucose concentration and elevation of the lactate/pyruvate ratio over time. The LD showed flow with the femoral head in situ and lack of flow when the femoral head was removed. INTERPRETATION: The use of MD was established in the human femoral head. Ischemic levels were detected within 2 h of cessation of blood flow in most patients.

AB - BACKGROUND: If it would be possible to detect lack of flow and/or the development of ischemia in bone, we might have a way of predicting whether a broken bone will heal. We established microdialysis (MD) and laser Doppler (LD) flow measurement in the human femoral head in order to be able to detect ischemia and measure changes in blood flow. MATERIAL AND METHODS: In 9 patients undergoing total hip arthroplasty for primary osteoarthrosis, two MD catheters were inserted into the femoral head through two drill holes after the blood flow had been visualized by LD. Then primary samples were collected with the femoral head in situ; thereafter, the head was removed and samples were collected over the following 4 hours ex vivo. The variables obtained by MD were concentrations of glucose, lactate, pyruvate, and glycerol in extracellular fluid. RESULTS: The results showed development of ischemia with a statistically significant decrease in glucose concentration and elevation of the lactate/pyruvate ratio over time. The LD showed flow with the femoral head in situ and lack of flow when the femoral head was removed. INTERPRETATION: The use of MD was established in the human femoral head. Ischemic levels were detected within 2 h of cessation of blood flow in most patients.

U2 - 10.1080/17453670610013420

DO - 10.1080/17453670610013420

M3 - Journal article

C2 - 17453393

VL - 78

SP - 56

EP - 62

JO - Acta Orthopaedica

JF - Acta Orthopaedica

SN - 1745-3674

IS - 1

ER -

ID: 252055895