Bioimpedance and Duration of Organ Dysfunction in Septic Shock - A Prospective Observational Study
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Bioimpedance and Duration of Organ Dysfunction in Septic Shock - A Prospective Observational Study. / Koch, Ellen Bjerre; Madsen, Janne M.; Wichmann, Sine; Bestle, Morten H.; Itenov, Theis S.
In: Journal of Intensive Care Medicine, Vol. 38, No. 10, 2023, p. 966-974.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Bioimpedance and Duration of Organ Dysfunction in Septic Shock - A Prospective Observational Study
AU - Koch, Ellen Bjerre
AU - Madsen, Janne M.
AU - Wichmann, Sine
AU - Bestle, Morten H.
AU - Itenov, Theis S.
N1 - Publisher Copyright: © The Author(s) 2023.
PY - 2023
Y1 - 2023
N2 - Rationale: Bioimpedance may be a useful tool to guide fluid treatment and avoid organ dysfunction related to fluid overload. Objective: We examined the correlation between bioimpedance and organ dysfunction in patients with septic shock. Methods: Prospective observational study of adult intensive care unit patients fulfilling the sepsis-3 criteria. Bioimpedance was measured using a body composition monitor (BCM) and BioScan Touch i8 (MBS). We measured impedance at inclusion and after 24 h and reported the impedance, change in impedance, bioimpedance-derived fluid balance, and changes in bioimpedance-derived fluid balance. Organ markers on respiratory, circulatory, and kidney function and overall disease severity were ascertained on days 1–7. The effect of bioimpedance on the change in organ function was assessed by mixed effects linear models. We considered P <.01 as significant. Measurements and Main Results: Forty-nine patients were included. None of the single baseline measurements or derived fluid balances were associated with the course of organ dysfunction. Changes in impedance were associated with the course of overall disease severity (P <.001; with MBS), and with changes in noradrenaline dose (P <.001; with MBS) and fluid balance (P <.001; with BCM). The changes in bioimpedance-derived fluid balance were associated with changes in noradrenaline dose (P <.001; with BCM), cumulative fluid balances (P <.001; with MBS), and lactate concentrations (P <.001; with BCM). Conclusions: Changes in bioimpedance were correlated with the duration of overall organ failure, circulatory failure, and fluid status. Single measurements of bioimpedance were not associated with any changes in organ dysfunction.
AB - Rationale: Bioimpedance may be a useful tool to guide fluid treatment and avoid organ dysfunction related to fluid overload. Objective: We examined the correlation between bioimpedance and organ dysfunction in patients with septic shock. Methods: Prospective observational study of adult intensive care unit patients fulfilling the sepsis-3 criteria. Bioimpedance was measured using a body composition monitor (BCM) and BioScan Touch i8 (MBS). We measured impedance at inclusion and after 24 h and reported the impedance, change in impedance, bioimpedance-derived fluid balance, and changes in bioimpedance-derived fluid balance. Organ markers on respiratory, circulatory, and kidney function and overall disease severity were ascertained on days 1–7. The effect of bioimpedance on the change in organ function was assessed by mixed effects linear models. We considered P <.01 as significant. Measurements and Main Results: Forty-nine patients were included. None of the single baseline measurements or derived fluid balances were associated with the course of organ dysfunction. Changes in impedance were associated with the course of overall disease severity (P <.001; with MBS), and with changes in noradrenaline dose (P <.001; with MBS) and fluid balance (P <.001; with BCM). The changes in bioimpedance-derived fluid balance were associated with changes in noradrenaline dose (P <.001; with BCM), cumulative fluid balances (P <.001; with MBS), and lactate concentrations (P <.001; with BCM). Conclusions: Changes in bioimpedance were correlated with the duration of overall organ failure, circulatory failure, and fluid status. Single measurements of bioimpedance were not associated with any changes in organ dysfunction.
KW - bioimpedance
KW - fluid overload
KW - intensive care
KW - organ dysfunction
KW - septic shock
U2 - 10.1177/08850666231175819
DO - 10.1177/08850666231175819
M3 - Journal article
C2 - 37186782
AN - SCOPUS:85161637328
VL - 38
SP - 966
EP - 974
JO - Journal of Intensive Care Medicine
JF - Journal of Intensive Care Medicine
SN - 0885-0666
IS - 10
ER -
ID: 362463728