Beta-blockers in high-risk outpatients with chronic obstructive pulmonary disease are associated with all-cause mortality – The statuette cohort study
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Beta-blockers in high-risk outpatients with chronic obstructive pulmonary disease are associated with all-cause mortality – The statuette cohort study. / Damkjær, Mathias; Ulrik, Charlotte Suppli; Godtfredsen, Nina; Håkansson, Kjell E.J.
In: International Journal of COPD, Vol. 16, 2021, p. 2397-2406.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Beta-blockers in high-risk outpatients with chronic obstructive pulmonary disease are associated with all-cause mortality – The statuette cohort study
AU - Damkjær, Mathias
AU - Ulrik, Charlotte Suppli
AU - Godtfredsen, Nina
AU - Håkansson, Kjell E.J.
N1 - Publisher Copyright: © 2021 Damkjær et al.
PY - 2021
Y1 - 2021
N2 - Background: Beta-blockers have been proposed to improve COPD-related outcomes, yet studies report conflicting results. We aimed to investigate the effect of beta blockers on time-to-first exacerbation and all-cause mortality in high-risk COPD outpatients. Methods: All COPD outpatients managed at the Department of Respiratory Medicine, Copenhagen University Hospital – Hvidovre, Denmark in 2016 were followed for 3.5 years in this retrospective, registry-based cohort study. Outcomes were time-to-first acute exacerbation of COPD (AECOPD) or death. The association was estimated using time-varying crude and multivariable Cox proportional hazard regression adjusted for age, sex, BMI, use of COPD medication, smoking status, cardiovascular disease and COPD severity. Results: The cohort comprised 950 COPD outpatients, mean age 71 (SD 11) years, and FEV1 44% predicted (IQR 33%; 57%). The annual exacerbation rate was 0.88 (SD 1.68) and 211 patients (22%) had a history of hospitalization requiring AECOPD within 12 months. Of the enrolled patients, 247 (26%) were prescribed beta blockers. Beta-blocker use was associated, although with borderline significance, with increased all-cause mortality (HR 1.37 (95% CI, 0.99 to 1.89, p = 0.059)). On the other hand, beta blocker use did not reduce the risk of AECOPD (HR = 0.89 (95% CI 0.71 to 1.10; p = 0.270)), which remained non-significant after stratifying for severity of exacerbations. Conclusion: We found an association between beta blocker use and all-cause mortality in high-risk COPD outpatients. No association was found between beta blocker use and risk of AECOPD.
AB - Background: Beta-blockers have been proposed to improve COPD-related outcomes, yet studies report conflicting results. We aimed to investigate the effect of beta blockers on time-to-first exacerbation and all-cause mortality in high-risk COPD outpatients. Methods: All COPD outpatients managed at the Department of Respiratory Medicine, Copenhagen University Hospital – Hvidovre, Denmark in 2016 were followed for 3.5 years in this retrospective, registry-based cohort study. Outcomes were time-to-first acute exacerbation of COPD (AECOPD) or death. The association was estimated using time-varying crude and multivariable Cox proportional hazard regression adjusted for age, sex, BMI, use of COPD medication, smoking status, cardiovascular disease and COPD severity. Results: The cohort comprised 950 COPD outpatients, mean age 71 (SD 11) years, and FEV1 44% predicted (IQR 33%; 57%). The annual exacerbation rate was 0.88 (SD 1.68) and 211 patients (22%) had a history of hospitalization requiring AECOPD within 12 months. Of the enrolled patients, 247 (26%) were prescribed beta blockers. Beta-blocker use was associated, although with borderline significance, with increased all-cause mortality (HR 1.37 (95% CI, 0.99 to 1.89, p = 0.059)). On the other hand, beta blocker use did not reduce the risk of AECOPD (HR = 0.89 (95% CI 0.71 to 1.10; p = 0.270)), which remained non-significant after stratifying for severity of exacerbations. Conclusion: We found an association between beta blocker use and all-cause mortality in high-risk COPD outpatients. No association was found between beta blocker use and risk of AECOPD.
KW - Beta-blockers
KW - Cardiovascular disease
KW - Chronic obstructive pulmonary disease
KW - Exacerbations
KW - Mortality
U2 - 10.2147/COPD.S315151
DO - 10.2147/COPD.S315151
M3 - Journal article
C2 - 34465987
AN - SCOPUS:85113788220
VL - 16
SP - 2397
EP - 2406
JO - International Journal of COPD
JF - International Journal of COPD
SN - 1178-2005
ER -
ID: 279282183