Benefits and Harms of Exercise Therapy for Patients With Diabetic Foot Ulcers: A Systematic Review
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Benefits and Harms of Exercise Therapy for Patients With Diabetic Foot Ulcers : A Systematic Review. / Aagaard, Thomas Vedste; Moeini, Sahar; Skou, Soren T.; Madsen, Ulla Riis; Brorson, Stig.
In: International Journal of Lower Extremity Wounds, Vol. 21, No. 3, 2022, p. 219-233.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Benefits and Harms of Exercise Therapy for Patients With Diabetic Foot Ulcers
T2 - A Systematic Review
AU - Aagaard, Thomas Vedste
AU - Moeini, Sahar
AU - Skou, Soren T.
AU - Madsen, Ulla Riis
AU - Brorson, Stig
PY - 2022
Y1 - 2022
N2 - AimExercise therapy is a core element in the treatment of diabetes, but the benefits and harms for patients with a diabetic foot ulcer (DFU) are unknown. We therefore aimed to systematically review the benefits on health-related quality of life (HRQoL) and harms of exercise therapy for patients with DFU.MethodsWe searched 6 major databases. We performed citation and reference searches of included studies and contacted authors of ongoing trials. We included randomized controlled trials (RCTs) to assess potential benefits on HRQoL and harms of exercise therapy. Observational studies were included to identify potential harms of exercise therapy.ResultsWe included 10 published publications of 9 trials and results from 2 unpublished trials including a total of 281 individuals with DFUs receiving various forms of exercise therapy. Due to lack of HRQoL measurements and high heterogeneity, it was not possible to perform meta-analyses. Results on HRQoL was present in one unpublished study. Harms reported ranged from musculoskeletal problems, increased wound size, to amputation; however, no safe conclusions could be drawn from the available data due to high heterogeneity and risk of bias in the trials.Conclusions/InterpretationProtective strategies are often preferred over therapeutic exercise that might have unforeseen consequences for patients over time. Based on the current literature, no evidence-based recommendations can be provided on the benefits and harms of exercise therapy for patients with DFUs. Well-conducted RCTs are needed to guide rehabilitation including detailed description of adverse events and an exercise program in a semisupervised or fully supervised setting.
AB - AimExercise therapy is a core element in the treatment of diabetes, but the benefits and harms for patients with a diabetic foot ulcer (DFU) are unknown. We therefore aimed to systematically review the benefits on health-related quality of life (HRQoL) and harms of exercise therapy for patients with DFU.MethodsWe searched 6 major databases. We performed citation and reference searches of included studies and contacted authors of ongoing trials. We included randomized controlled trials (RCTs) to assess potential benefits on HRQoL and harms of exercise therapy. Observational studies were included to identify potential harms of exercise therapy.ResultsWe included 10 published publications of 9 trials and results from 2 unpublished trials including a total of 281 individuals with DFUs receiving various forms of exercise therapy. Due to lack of HRQoL measurements and high heterogeneity, it was not possible to perform meta-analyses. Results on HRQoL was present in one unpublished study. Harms reported ranged from musculoskeletal problems, increased wound size, to amputation; however, no safe conclusions could be drawn from the available data due to high heterogeneity and risk of bias in the trials.Conclusions/InterpretationProtective strategies are often preferred over therapeutic exercise that might have unforeseen consequences for patients over time. Based on the current literature, no evidence-based recommendations can be provided on the benefits and harms of exercise therapy for patients with DFUs. Well-conducted RCTs are needed to guide rehabilitation including detailed description of adverse events and an exercise program in a semisupervised or fully supervised setting.
KW - diabetic foot ulcers
KW - wound care
KW - health-related quality of life assessments
U2 - 10.1177/1534734620954066
DO - 10.1177/1534734620954066
M3 - Journal article
C2 - 32924691
VL - 21
SP - 219
EP - 233
JO - International Journal of Lower Extremity Wounds
JF - International Journal of Lower Extremity Wounds
SN - 1534-7346
IS - 3
ER -
ID: 250555955