Basal very low-density lipoprotein metabolism in response to exercise: mechanisms of hypotriacylglycerolemia
Research output: Contribution to journal › Review › Research › peer-review
Although the hypotriacylglycerolemic effect of exercise was described more than 40 years ago, the mechanisms responsible for triacylglycerol (TAG)-lowering have just recently started to be elucidated. Delayed-onset hypotriacylglycerolemia in the basal state, 1 day after a single bout of endurance exercise is due to augmented efficiency of very low-density lipoprotein (VLDL)-TAG removal from the circulation, likely mediated by the secretion of fewer but TAG-richer VLDL particles from the liver; exercise-induced changes in skeletal muscle lipoprotein lipase are more likely a contributing rather than the primary factor of TAG-lowering. This illustrates, in vivo, how changes in VLDL-apolipoprotein B-100 metabolism in the liver can effect changes in VLDL-TAG metabolism in the periphery. The exercise-induced increase in basal VLDL-TAG clearance rate plateaus at approximately 40%, whereas the threshold of energy that needs to be expended during endurance exercise lies near or above 500-600 kcal. Resistance exercise is more potent than endurance exercise in this respect. Exercise-induced changes in basal hepatic VLDL-TAG secretion 12-24h after exercise are not negligible but span around zero; available data indicates that reduced hepatic VLDL-TAG secretion rate may be responsible for the persistence of hypotriacylglycerolemia at later time points (>or=48 h) after exercise cessation, or following training. Our understanding of the mechanisms leading to TAG-lowering after exercise has advanced considerably in recent years, but much remains to be learned.
Original language | English |
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Journal | Progress in Lipid Research |
Volume | 48 |
Issue number | 3-4 |
Pages (from-to) | 171-190 |
Number of pages | 20 |
ISSN | 0163-7827 |
DOIs | |
Publication status | Published - 2009 |
Externally published | Yes |
- Animals, Apolipoproteins/metabolism, Basal Metabolism/physiology, Exercise/physiology, Humans, Lipoprotein Lipase/metabolism, Lipoproteins, VLDL/metabolism, Liver/enzymology, Triglycerides/metabolism
Research areas
ID: 290673244