Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications

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Axonal transport defects and neurodegeneration : Molecular mechanisms and therapeutic implications. / Guo, Wenting; Stoklund Dittlau, Katarina; Van Den Bosch, Ludo.

In: Seminars in Cell and Developmental Biology, Vol. 99, 2020, p. 133-150.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Guo, W, Stoklund Dittlau, K & Van Den Bosch, L 2020, 'Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications', Seminars in Cell and Developmental Biology, vol. 99, pp. 133-150. https://doi.org/10.1016/j.semcdb.2019.07.010

APA

Guo, W., Stoklund Dittlau, K., & Van Den Bosch, L. (2020). Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications. Seminars in Cell and Developmental Biology, 99, 133-150. https://doi.org/10.1016/j.semcdb.2019.07.010

Vancouver

Guo W, Stoklund Dittlau K, Van Den Bosch L. Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications. Seminars in Cell and Developmental Biology. 2020;99:133-150. https://doi.org/10.1016/j.semcdb.2019.07.010

Author

Guo, Wenting ; Stoklund Dittlau, Katarina ; Van Den Bosch, Ludo. / Axonal transport defects and neurodegeneration : Molecular mechanisms and therapeutic implications. In: Seminars in Cell and Developmental Biology. 2020 ; Vol. 99. pp. 133-150.

Bibtex

@article{52b6fcd71f604247ae73ec2a96d3a43c,
title = "Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications",
abstract = "Because of the extremely polarized morphology, the proper functioning of neurons largely relies on the efficient cargo transport along the axon. Axonal transport defects have been reported in multiple neurodegenerative diseases as an early pathological feature. The discovery of mutations in human genes involved in the transport machinery provide a direct causative relationship between axonal transport defects and neurodegeneration. Here, we summarize the current genetic findings related to axonal transport in neurodegenerative diseases, and we discuss the relationship between axonal transport defects and other pathological changes observed in neurodegeneration. In addition, we summarize the therapeutic approaches targeting the axonal transport machinery in studies of neurodegenerative diseases. Finally, we review the technical advances in tracking axonal transport both in vivo and in vitro.",
keywords = "Amyotrophic lateral sclerosis, Axonal transport, Neurodegenerative diseases, Peripheral neuropathy",
author = "Wenting Guo and {Stoklund Dittlau}, Katarina and {Van Den Bosch}, Ludo",
note = "Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2020",
doi = "10.1016/j.semcdb.2019.07.010",
language = "English",
volume = "99",
pages = "133--150",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Axonal transport defects and neurodegeneration

T2 - Molecular mechanisms and therapeutic implications

AU - Guo, Wenting

AU - Stoklund Dittlau, Katarina

AU - Van Den Bosch, Ludo

N1 - Publisher Copyright: © 2019 The Authors

PY - 2020

Y1 - 2020

N2 - Because of the extremely polarized morphology, the proper functioning of neurons largely relies on the efficient cargo transport along the axon. Axonal transport defects have been reported in multiple neurodegenerative diseases as an early pathological feature. The discovery of mutations in human genes involved in the transport machinery provide a direct causative relationship between axonal transport defects and neurodegeneration. Here, we summarize the current genetic findings related to axonal transport in neurodegenerative diseases, and we discuss the relationship between axonal transport defects and other pathological changes observed in neurodegeneration. In addition, we summarize the therapeutic approaches targeting the axonal transport machinery in studies of neurodegenerative diseases. Finally, we review the technical advances in tracking axonal transport both in vivo and in vitro.

AB - Because of the extremely polarized morphology, the proper functioning of neurons largely relies on the efficient cargo transport along the axon. Axonal transport defects have been reported in multiple neurodegenerative diseases as an early pathological feature. The discovery of mutations in human genes involved in the transport machinery provide a direct causative relationship between axonal transport defects and neurodegeneration. Here, we summarize the current genetic findings related to axonal transport in neurodegenerative diseases, and we discuss the relationship between axonal transport defects and other pathological changes observed in neurodegeneration. In addition, we summarize the therapeutic approaches targeting the axonal transport machinery in studies of neurodegenerative diseases. Finally, we review the technical advances in tracking axonal transport both in vivo and in vitro.

KW - Amyotrophic lateral sclerosis

KW - Axonal transport

KW - Neurodegenerative diseases

KW - Peripheral neuropathy

U2 - 10.1016/j.semcdb.2019.07.010

DO - 10.1016/j.semcdb.2019.07.010

M3 - Review

C2 - 31542222

AN - SCOPUS:85072261132

VL - 99

SP - 133

EP - 150

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

ER -

ID: 368623300