Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis

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Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis. / Müller, K; Hansen, M B; Zak, M; Nielsen, S; Pedersen, F K; de Nully, P; Bendtzen, K.

In: Scandinavian Journal of Rheumatology, Vol. 25, No. 3, 01.01.1996, p. 164-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Müller, K, Hansen, MB, Zak, M, Nielsen, S, Pedersen, FK, de Nully, P & Bendtzen, K 1996, 'Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis', Scandinavian Journal of Rheumatology, vol. 25, no. 3, pp. 164-7.

APA

Müller, K., Hansen, M. B., Zak, M., Nielsen, S., Pedersen, F. K., de Nully, P., & Bendtzen, K. (1996). Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis. Scandinavian Journal of Rheumatology, 25(3), 164-7.

Vancouver

Müller K, Hansen MB, Zak M, Nielsen S, Pedersen FK, de Nully P et al. Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis. Scandinavian Journal of Rheumatology. 1996 Jan 1;25(3):164-7.

Author

Müller, K ; Hansen, M B ; Zak, M ; Nielsen, S ; Pedersen, F K ; de Nully, P ; Bendtzen, K. / Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis. In: Scandinavian Journal of Rheumatology. 1996 ; Vol. 25, No. 3. pp. 164-7.

Bibtex

@article{88fe1962e4d34bd8acdcb4314bcb53cd,
title = "Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis",
abstract = "Antibodies against interleukin-1 alpha (aAb-IL-1 alpha) have previously been demonstrated in sera of healthy adults and in patients with inflammatory diseases. In the present investigation the occurrence of aAb-IL-1 alpha was examined by second antibody precipitation technique in sera from umbilical cords (n = 11), children (n = 45), and adults (n = 20), as well as in 51 patients with juvenile chronic arthritis (JCA) of pauciarticular (n = 34), polyarticular (n = 8), or systemic onset type (n = 9). RESULTS. The frequency of positive sera was significantly lower in children than in cord blood and adults as were the levels of aAb-IL-1 alpha (p <0.0001). In the non-neonatal group of individuals the levels of aAb-IL-1 alpha correlated positively with age (r = 0.394, p = 0.0015). The frequency of sera positive for aAb-IL-1 alpha was higher in the JCA patients, as were the levels (p <0.005), and correlated positively with disease activity as evaluated by joint score and visual analogue score.",
keywords = "Adult, Age Factors, Arthritis, Juvenile Rheumatoid, Autoantibodies, Child, Female, Fetal Blood, Humans, Interleukin-1, Male",
author = "K M{\"u}ller and Hansen, {M B} and M Zak and S Nielsen and Pedersen, {F K} and {de Nully}, P and K Bendtzen",
year = "1996",
month = jan,
day = "1",
language = "English",
volume = "25",
pages = "164--7",
journal = "Scandinavian Journal of Rheumatology",
issn = "0300-9742",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis

AU - Müller, K

AU - Hansen, M B

AU - Zak, M

AU - Nielsen, S

AU - Pedersen, F K

AU - de Nully, P

AU - Bendtzen, K

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Antibodies against interleukin-1 alpha (aAb-IL-1 alpha) have previously been demonstrated in sera of healthy adults and in patients with inflammatory diseases. In the present investigation the occurrence of aAb-IL-1 alpha was examined by second antibody precipitation technique in sera from umbilical cords (n = 11), children (n = 45), and adults (n = 20), as well as in 51 patients with juvenile chronic arthritis (JCA) of pauciarticular (n = 34), polyarticular (n = 8), or systemic onset type (n = 9). RESULTS. The frequency of positive sera was significantly lower in children than in cord blood and adults as were the levels of aAb-IL-1 alpha (p <0.0001). In the non-neonatal group of individuals the levels of aAb-IL-1 alpha correlated positively with age (r = 0.394, p = 0.0015). The frequency of sera positive for aAb-IL-1 alpha was higher in the JCA patients, as were the levels (p <0.005), and correlated positively with disease activity as evaluated by joint score and visual analogue score.

AB - Antibodies against interleukin-1 alpha (aAb-IL-1 alpha) have previously been demonstrated in sera of healthy adults and in patients with inflammatory diseases. In the present investigation the occurrence of aAb-IL-1 alpha was examined by second antibody precipitation technique in sera from umbilical cords (n = 11), children (n = 45), and adults (n = 20), as well as in 51 patients with juvenile chronic arthritis (JCA) of pauciarticular (n = 34), polyarticular (n = 8), or systemic onset type (n = 9). RESULTS. The frequency of positive sera was significantly lower in children than in cord blood and adults as were the levels of aAb-IL-1 alpha (p <0.0001). In the non-neonatal group of individuals the levels of aAb-IL-1 alpha correlated positively with age (r = 0.394, p = 0.0015). The frequency of sera positive for aAb-IL-1 alpha was higher in the JCA patients, as were the levels (p <0.005), and correlated positively with disease activity as evaluated by joint score and visual analogue score.

KW - Adult

KW - Age Factors

KW - Arthritis, Juvenile Rheumatoid

KW - Autoantibodies

KW - Child

KW - Female

KW - Fetal Blood

KW - Humans

KW - Interleukin-1

KW - Male

M3 - Journal article

C2 - 8668960

VL - 25

SP - 164

EP - 167

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

SN - 0300-9742

IS - 3

ER -

ID: 33494141