TY - JOUR

T1 - At new heights - endodermal lineages in development and disease

AU - Ober, Elke A

AU - Grapin-Botton, Anne

N1 - © 2015. Published by The Company of Biologists Ltd.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - The endoderm gives rise to diverse tissues and organs that are essential for the homeostasis and metabolism of the organism: the thymus, thyroid, lungs, liver and pancreas, and the functionally diverse domains of the digestive tract. Classically, the endoderm, the 'innermost germ layer', was in the shadow of the ectoderm and mesoderm. However, at a recent Keystone meeting it took center stage, revealing astonishing progress in dissecting the mechanisms underlying the development and malfunction of the endodermal organs. In vitro cultures of stem and progenitor cells have become widespread, with remarkable success in differentiating three-dimensional organoids, which - in a new turn for the field - can be used as disease models.

AB - The endoderm gives rise to diverse tissues and organs that are essential for the homeostasis and metabolism of the organism: the thymus, thyroid, lungs, liver and pancreas, and the functionally diverse domains of the digestive tract. Classically, the endoderm, the 'innermost germ layer', was in the shadow of the ectoderm and mesoderm. However, at a recent Keystone meeting it took center stage, revealing astonishing progress in dissecting the mechanisms underlying the development and malfunction of the endodermal organs. In vitro cultures of stem and progenitor cells have become widespread, with remarkable success in differentiating three-dimensional organoids, which - in a new turn for the field - can be used as disease models.

U2 - 10.1242/dev.121095

DO - 10.1242/dev.121095

M3 - Journal article

C2 - 26015535

VL - 142

SP - 1912

EP - 1917

JO - Development

JF - Development

SN - 0950-1991

IS - 11

ER -