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Association of vitamin D levels and risk of ovarian cancer : a Mendelian randomization study. / Ong, Jue-Sheng; Cuellar-Partida, Gabriel; Lu, Yi; Ovarian Cancer Study, Australian; Fasching, Peter A; Hein, Alexander; Burghaus, Stefanie; Beckmann, Matthias W; Lambrechts, Diether; Van Nieuwenhuysen, Els; Vergote, Ignace; Vanderstichele, Adriaan; Anne Doherty, Jennifer; Anne Rossing, Mary; Chang-Claude, Jenny; Eilber, Ursula; Rudolph, Anja; Wang-Gohrke, Shan; Goodman, Marc T; Bogdanova, Natalia; Dörk, Thilo; Dürst, Matthias; Hillemanns, Peter; Runnebaum, Ingo B; Antonenkova, Natalia; Butzow, Ralf; Leminen, Arto; Nevanlinna, Heli; Pelttari, Liisa M; Edwards, Robert P; Kelley, Joseph L; Modugno, Francesmary; Moysich, Kirsten B; Ness, Roberta B; Cannioto, Rikki; Høgdall, Estrid; Høgdall, Claus K; Jensen, Allan; Giles, Graham G; Bruinsma, Fiona; Kjaer, Susanne K; Hildebrandt, Michelle At; Liang, Dong; Lu, Karen H; Wu, Xifeng; Bisogna, Maria; Dao, Fanny; Levine, Douglas A; Cramer, Daniel W; Terry, Kathryn L; Tworoger, Shelley S; Stampfer, Meir; Missmer, Stacey; Bjorge, Line; Salvesen, Helga B; Kopperud, Reidun K; Bischof, Katharina; Aben, Katja Kh; Kiemeney, Lambertus A; Massuger, Leon Fag; Brooks-Wilson, Angela; Olson, Sara H; McGuire, Valerie; Rothstein, Joseph H; Sieh, Weiva; Whittemore, Alice S; Cook, Linda S; Le, Nhu D; Blake Gilks, C; Gronwald, Jacek; Jakubowska, Anna; Lubiński, Jan; Kluz, Tomasz; Song, Honglin; Tyrer, Jonathan P; Wentzensen, Nicolas; Brinton, Louise; Trabert, Britton; Lissowska, Jolanta; McLaughlin, John R; Narod, Steven A; Phelan, Catherine; Anton-Culver, Hoda; Ziogas, Argyrios; Eccles, Diana; Campbell, Ian; Gayther, Simon A; Gentry-Maharaj, Aleksandra; Menon, Usha; Ramus, Susan J; Wu, Anna H; Dansonka-Mieszkowska, Agnieszka; Kupryjanczyk, Jolanta; Timorek, Agnieszka; Szafron, Lukasz; Cunningham, Julie M; Fridley, Brooke L; Winham, Stacey J; Bandera, Elisa V; Poole, Elizabeth M; Morgan, Terry K; Risch, Harvey A; Goode, Ellen L; Schildkraut, Joellen M; Pearce, Celeste L; Berchuck, Andrew; Pharoah, Paul Dp; Chenevix-Trench, Georgia; Gharahkhani, Puya; Neale, Rachel E; Webb, Penelope M; MacGregor, Stuart.
In:
International Journal of Epidemiology, Vol. 45, No. 5, 10.2016, p. 1619-1630.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Ong, J-S, Cuellar-Partida, G, Lu, Y, Ovarian Cancer Study, A, Fasching, PA, Hein, A, Burghaus, S, Beckmann, MW, Lambrechts, D, Van Nieuwenhuysen, E, Vergote, I, Vanderstichele, A, Anne Doherty, J, Anne Rossing, M, Chang-Claude, J, Eilber, U, Rudolph, A, Wang-Gohrke, S, Goodman, MT, Bogdanova, N, Dörk, T, Dürst, M, Hillemanns, P, Runnebaum, IB, Antonenkova, N, Butzow, R, Leminen, A, Nevanlinna, H, Pelttari, LM, Edwards, RP, Kelley, JL, Modugno, F, Moysich, KB, Ness, RB, Cannioto, R
, Høgdall, E, Høgdall, CK, Jensen, A, Giles, GG, Bruinsma, F
, Kjaer, SK, Hildebrandt, MA, Liang, D, Lu, KH, Wu, X, Bisogna, M, Dao, F, Levine, DA, Cramer, DW, Terry, KL, Tworoger, SS, Stampfer, M, Missmer, S, Bjorge, L, Salvesen, HB, Kopperud, RK, Bischof, K, Aben, KK, Kiemeney, LA, Massuger, LF, Brooks-Wilson, A, Olson, SH, McGuire, V, Rothstein, JH, Sieh, W, Whittemore, AS, Cook, LS, Le, ND, Blake Gilks, C, Gronwald, J, Jakubowska, A, Lubiński, J, Kluz, T, Song, H, Tyrer, JP, Wentzensen, N, Brinton, L, Trabert, B, Lissowska, J, McLaughlin, JR, Narod, SA, Phelan, C, Anton-Culver, H, Ziogas, A, Eccles, D, Campbell, I, Gayther, SA, Gentry-Maharaj, A, Menon, U, Ramus, SJ, Wu, AH, Dansonka-Mieszkowska, A, Kupryjanczyk, J, Timorek, A, Szafron, L, Cunningham, JM, Fridley, BL, Winham, SJ, Bandera, EV, Poole, EM, Morgan, TK, Risch, HA, Goode, EL, Schildkraut, JM, Pearce, CL, Berchuck, A, Pharoah, PD, Chenevix-Trench, G, Gharahkhani, P, Neale, RE, Webb, PM & MacGregor, S 2016, '
Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study',
International Journal of Epidemiology, vol. 45, no. 5, pp. 1619-1630.
https://doi.org/10.1093/ije/dyw207
APA
Ong, J-S., Cuellar-Partida, G., Lu, Y., Ovarian Cancer Study, A., Fasching, P. A., Hein, A., Burghaus, S., Beckmann, M. W., Lambrechts, D., Van Nieuwenhuysen, E., Vergote, I., Vanderstichele, A., Anne Doherty, J., Anne Rossing, M., Chang-Claude, J., Eilber, U., Rudolph, A., Wang-Gohrke, S., Goodman, M. T., ... MacGregor, S. (2016).
Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.
International Journal of Epidemiology,
45(5), 1619-1630.
https://doi.org/10.1093/ije/dyw207
Vancouver
Ong J-S, Cuellar-Partida G, Lu Y, Ovarian Cancer Study A, Fasching PA, Hein A et al.
Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.
International Journal of Epidemiology. 2016 Oct;45(5):1619-1630.
https://doi.org/10.1093/ije/dyw207
Author
Ong, Jue-Sheng ; Cuellar-Partida, Gabriel ; Lu, Yi ; Ovarian Cancer Study, Australian ; Fasching, Peter A ; Hein, Alexander ; Burghaus, Stefanie ; Beckmann, Matthias W ; Lambrechts, Diether ; Van Nieuwenhuysen, Els ; Vergote, Ignace ; Vanderstichele, Adriaan ; Anne Doherty, Jennifer ; Anne Rossing, Mary ; Chang-Claude, Jenny ; Eilber, Ursula ; Rudolph, Anja ; Wang-Gohrke, Shan ; Goodman, Marc T ; Bogdanova, Natalia ; Dörk, Thilo ; Dürst, Matthias ; Hillemanns, Peter ; Runnebaum, Ingo B ; Antonenkova, Natalia ; Butzow, Ralf ; Leminen, Arto ; Nevanlinna, Heli ; Pelttari, Liisa M ; Edwards, Robert P ; Kelley, Joseph L ; Modugno, Francesmary ; Moysich, Kirsten B ; Ness, Roberta B ; Cannioto, Rikki ; Høgdall, Estrid ; Høgdall, Claus K ; Jensen, Allan ; Giles, Graham G ; Bruinsma, Fiona ; Kjaer, Susanne K ; Hildebrandt, Michelle At ; Liang, Dong ; Lu, Karen H ; Wu, Xifeng ; Bisogna, Maria ; Dao, Fanny ; Levine, Douglas A ; Cramer, Daniel W ; Terry, Kathryn L ; Tworoger, Shelley S ; Stampfer, Meir ; Missmer, Stacey ; Bjorge, Line ; Salvesen, Helga B ; Kopperud, Reidun K ; Bischof, Katharina ; Aben, Katja Kh ; Kiemeney, Lambertus A ; Massuger, Leon Fag ; Brooks-Wilson, Angela ; Olson, Sara H ; McGuire, Valerie ; Rothstein, Joseph H ; Sieh, Weiva ; Whittemore, Alice S ; Cook, Linda S ; Le, Nhu D ; Blake Gilks, C ; Gronwald, Jacek ; Jakubowska, Anna ; Lubiński, Jan ; Kluz, Tomasz ; Song, Honglin ; Tyrer, Jonathan P ; Wentzensen, Nicolas ; Brinton, Louise ; Trabert, Britton ; Lissowska, Jolanta ; McLaughlin, John R ; Narod, Steven A ; Phelan, Catherine ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Eccles, Diana ; Campbell, Ian ; Gayther, Simon A ; Gentry-Maharaj, Aleksandra ; Menon, Usha ; Ramus, Susan J ; Wu, Anna H ; Dansonka-Mieszkowska, Agnieszka ; Kupryjanczyk, Jolanta ; Timorek, Agnieszka ; Szafron, Lukasz ; Cunningham, Julie M ; Fridley, Brooke L ; Winham, Stacey J ; Bandera, Elisa V ; Poole, Elizabeth M ; Morgan, Terry K ; Risch, Harvey A ; Goode, Ellen L ; Schildkraut, Joellen M ; Pearce, Celeste L ; Berchuck, Andrew ; Pharoah, Paul Dp ; Chenevix-Trench, Georgia ; Gharahkhani, Puya ; Neale, Rachel E ; Webb, Penelope M ; MacGregor, Stuart. / Association of vitamin D levels and risk of ovarian cancer : a Mendelian randomization study. In: International Journal of Epidemiology. 2016 ; Vol. 45, No. 5. pp. 1619-1630.
Bibtex
@article{ac59e282c5c4450592c56de6a905e394,
title = "Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study",
abstract = "BACKGROUND: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer.METHODS: We employed SNPs with well-established associations with 25(OH)D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases).RESULTS: The odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1.27 (95% confidence interval: 1.06 to 1.51) per 20 nmol/L decrease in 25(OH)D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1.54 (1.19, 2.01).CONCLUSIONS: Genetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer.",
author = "Jue-Sheng Ong and Gabriel Cuellar-Partida and Yi Lu and {Ovarian Cancer Study}, Australian and Fasching, {Peter A} and Alexander Hein and Stefanie Burghaus and Beckmann, {Matthias W} and Diether Lambrechts and {Van Nieuwenhuysen}, Els and Ignace Vergote and Adriaan Vanderstichele and {Anne Doherty}, Jennifer and {Anne Rossing}, Mary and Jenny Chang-Claude and Ursula Eilber and Anja Rudolph and Shan Wang-Gohrke and Goodman, {Marc T} and Natalia Bogdanova and Thilo D{\"o}rk and Matthias D{\"u}rst and Peter Hillemanns and Runnebaum, {Ingo B} and Natalia Antonenkova and Ralf Butzow and Arto Leminen and Heli Nevanlinna and Pelttari, {Liisa M} and Edwards, {Robert P} and Kelley, {Joseph L} and Francesmary Modugno and Moysich, {Kirsten B} and Ness, {Roberta B} and Rikki Cannioto and Estrid H{\o}gdall and H{\o}gdall, {Claus K} and Allan Jensen and Giles, {Graham G} and Fiona Bruinsma and Kjaer, {Susanne K} and Hildebrandt, {Michelle At} and Dong Liang and Lu, {Karen H} and Xifeng Wu and Maria Bisogna and Fanny Dao and Levine, {Douglas A} and Cramer, {Daniel W} and Terry, {Kathryn L} and Tworoger, {Shelley S} and Meir Stampfer and Stacey Missmer and Line Bjorge and Salvesen, {Helga B} and Kopperud, {Reidun K} and Katharina Bischof and Aben, {Katja Kh} and Kiemeney, {Lambertus A} and Massuger, {Leon Fag} and Angela Brooks-Wilson and Olson, {Sara H} and Valerie McGuire and Rothstein, {Joseph H} and Weiva Sieh and Whittemore, {Alice S} and Cook, {Linda S} and Le, {Nhu D} and {Blake Gilks}, C and Jacek Gronwald and Anna Jakubowska and Jan Lubi{\'n}ski and Tomasz Kluz and Honglin Song and Tyrer, {Jonathan P} and Nicolas Wentzensen and Louise Brinton and Britton Trabert and Jolanta Lissowska and McLaughlin, {John R} and Narod, {Steven A} and Catherine Phelan and Hoda Anton-Culver and Argyrios Ziogas and Diana Eccles and Ian Campbell and Gayther, {Simon A} and Aleksandra Gentry-Maharaj and Usha Menon and Ramus, {Susan J} and Wu, {Anna H} and Agnieszka Dansonka-Mieszkowska and Jolanta Kupryjanczyk and Agnieszka Timorek and Lukasz Szafron and Cunningham, {Julie M} and Fridley, {Brooke L} and Winham, {Stacey J} and Bandera, {Elisa V} and Poole, {Elizabeth M} and Morgan, {Terry K} and Risch, {Harvey A} and Goode, {Ellen L} and Schildkraut, {Joellen M} and Pearce, {Celeste L} and Andrew Berchuck and Pharoah, {Paul Dp} and Georgia Chenevix-Trench and Puya Gharahkhani and Neale, {Rachel E} and Webb, {Penelope M} and Stuart MacGregor",
note = "{\textcopyright} The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.",
year = "2016",
month = oct,
doi = "10.1093/ije/dyw207",
language = "English",
volume = "45",
pages = "1619--1630",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "5",
}
RIS
TY - JOUR
T1 - Association of vitamin D levels and risk of ovarian cancer
T2 - a Mendelian randomization study
AU - Ong, Jue-Sheng
AU - Cuellar-Partida, Gabriel
AU - Lu, Yi
AU - Ovarian Cancer Study, Australian
AU - Fasching, Peter A
AU - Hein, Alexander
AU - Burghaus, Stefanie
AU - Beckmann, Matthias W
AU - Lambrechts, Diether
AU - Van Nieuwenhuysen, Els
AU - Vergote, Ignace
AU - Vanderstichele, Adriaan
AU - Anne Doherty, Jennifer
AU - Anne Rossing, Mary
AU - Chang-Claude, Jenny
AU - Eilber, Ursula
AU - Rudolph, Anja
AU - Wang-Gohrke, Shan
AU - Goodman, Marc T
AU - Bogdanova, Natalia
AU - Dörk, Thilo
AU - Dürst, Matthias
AU - Hillemanns, Peter
AU - Runnebaum, Ingo B
AU - Antonenkova, Natalia
AU - Butzow, Ralf
AU - Leminen, Arto
AU - Nevanlinna, Heli
AU - Pelttari, Liisa M
AU - Edwards, Robert P
AU - Kelley, Joseph L
AU - Modugno, Francesmary
AU - Moysich, Kirsten B
AU - Ness, Roberta B
AU - Cannioto, Rikki
AU - Høgdall, Estrid
AU - Høgdall, Claus K
AU - Jensen, Allan
AU - Giles, Graham G
AU - Bruinsma, Fiona
AU - Kjaer, Susanne K
AU - Hildebrandt, Michelle At
AU - Liang, Dong
AU - Lu, Karen H
AU - Wu, Xifeng
AU - Bisogna, Maria
AU - Dao, Fanny
AU - Levine, Douglas A
AU - Cramer, Daniel W
AU - Terry, Kathryn L
AU - Tworoger, Shelley S
AU - Stampfer, Meir
AU - Missmer, Stacey
AU - Bjorge, Line
AU - Salvesen, Helga B
AU - Kopperud, Reidun K
AU - Bischof, Katharina
AU - Aben, Katja Kh
AU - Kiemeney, Lambertus A
AU - Massuger, Leon Fag
AU - Brooks-Wilson, Angela
AU - Olson, Sara H
AU - McGuire, Valerie
AU - Rothstein, Joseph H
AU - Sieh, Weiva
AU - Whittemore, Alice S
AU - Cook, Linda S
AU - Le, Nhu D
AU - Blake Gilks, C
AU - Gronwald, Jacek
AU - Jakubowska, Anna
AU - Lubiński, Jan
AU - Kluz, Tomasz
AU - Song, Honglin
AU - Tyrer, Jonathan P
AU - Wentzensen, Nicolas
AU - Brinton, Louise
AU - Trabert, Britton
AU - Lissowska, Jolanta
AU - McLaughlin, John R
AU - Narod, Steven A
AU - Phelan, Catherine
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Eccles, Diana
AU - Campbell, Ian
AU - Gayther, Simon A
AU - Gentry-Maharaj, Aleksandra
AU - Menon, Usha
AU - Ramus, Susan J
AU - Wu, Anna H
AU - Dansonka-Mieszkowska, Agnieszka
AU - Kupryjanczyk, Jolanta
AU - Timorek, Agnieszka
AU - Szafron, Lukasz
AU - Cunningham, Julie M
AU - Fridley, Brooke L
AU - Winham, Stacey J
AU - Bandera, Elisa V
AU - Poole, Elizabeth M
AU - Morgan, Terry K
AU - Risch, Harvey A
AU - Goode, Ellen L
AU - Schildkraut, Joellen M
AU - Pearce, Celeste L
AU - Berchuck, Andrew
AU - Pharoah, Paul Dp
AU - Chenevix-Trench, Georgia
AU - Gharahkhani, Puya
AU - Neale, Rachel E
AU - Webb, Penelope M
AU - MacGregor, Stuart
N1 - © The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.
PY - 2016/10
Y1 - 2016/10
N2 - BACKGROUND: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer.METHODS: We employed SNPs with well-established associations with 25(OH)D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases).RESULTS: The odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1.27 (95% confidence interval: 1.06 to 1.51) per 20 nmol/L decrease in 25(OH)D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1.54 (1.19, 2.01).CONCLUSIONS: Genetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer.
AB - BACKGROUND: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer.METHODS: We employed SNPs with well-established associations with 25(OH)D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases).RESULTS: The odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1.27 (95% confidence interval: 1.06 to 1.51) per 20 nmol/L decrease in 25(OH)D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1.54 (1.19, 2.01).CONCLUSIONS: Genetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer.
U2 - 10.1093/ije/dyw207
DO - 10.1093/ije/dyw207
M3 - Journal article
C2 - 27594614
VL - 45
SP - 1619
EP - 1630
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
SN - 0300-5771
IS - 5
ER -