Association of multiple sclerosis with incident diabetes: A nationwide cohort study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Association of multiple sclerosis with incident diabetes : A nationwide cohort study. / Jacobsen, Jeppe Ravn; Kristensen, Søren L.; Fosbøl, Emil L.; Køber, Lars; Westergaard, Lucas Malta; Persson, Frederik; Rossing, Peter; Rørth, Rasmus.
In: Diabetes and Metabolism, Vol. 50, No. 5, 101551, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Association of multiple sclerosis with incident diabetes
T2 - A nationwide cohort study
AU - Jacobsen, Jeppe Ravn
AU - Kristensen, Søren L.
AU - Fosbøl, Emil L.
AU - Køber, Lars
AU - Westergaard, Lucas Malta
AU - Persson, Frederik
AU - Rossing, Peter
AU - Rørth, Rasmus
N1 - Publisher Copyright: © 2024 Elsevier Masson SAS
PY - 2024
Y1 - 2024
N2 - Aim: Diabetes mellitus (DM) and multiple sclerosis (MS) are two common diseases known to worsen the trajectory of each other, yet it is unknown whether MS is associated with incident DM. Methods: Using Danish nationwide registries, we identified all patients aged 18–99 with a first-time primary or secondary discharge diagnosis with MS between 2000 and 2018, with no known DM. These patients were matched with control subjects from the background population in a 1:5 ratio based on age and sex, to assess their risk of DM. Results: A total of 13,376 patients with MS and 66,880 matched control subjects were included (33 % men; median age, 42 years [25th–75th percentile, 33–51]). During a median follow-up of 8.3 years (25th–75th percentile, 4.0–13.3), 467 (3.5 %) patients with MS and 2397 (3.6 %) control subjects were diagnosed with DM. The cumulative incidence of DM was similar among patients with MS and control subjects (95 % confidence interval [CI] 6.5 % [5.7–7.2 %] vs. 7.3 % [95 % CI 6.9–7.9 %], respectively), and adjusted analysis yielded a hazard ratio (HR) of 0.98 [95 % CI 0.89–1.09]). The overall risk of incident type 1 diabetes was low and yielded a HR of 1.60 [95 % CI 0.98–1.40] in patients with MS compared with control subject (P = 0.07). Conclusion: This study demonstrated that patients with MS had a similar risk of incident DM as compared to age- and sex matched controls from the background population.
AB - Aim: Diabetes mellitus (DM) and multiple sclerosis (MS) are two common diseases known to worsen the trajectory of each other, yet it is unknown whether MS is associated with incident DM. Methods: Using Danish nationwide registries, we identified all patients aged 18–99 with a first-time primary or secondary discharge diagnosis with MS between 2000 and 2018, with no known DM. These patients were matched with control subjects from the background population in a 1:5 ratio based on age and sex, to assess their risk of DM. Results: A total of 13,376 patients with MS and 66,880 matched control subjects were included (33 % men; median age, 42 years [25th–75th percentile, 33–51]). During a median follow-up of 8.3 years (25th–75th percentile, 4.0–13.3), 467 (3.5 %) patients with MS and 2397 (3.6 %) control subjects were diagnosed with DM. The cumulative incidence of DM was similar among patients with MS and control subjects (95 % confidence interval [CI] 6.5 % [5.7–7.2 %] vs. 7.3 % [95 % CI 6.9–7.9 %], respectively), and adjusted analysis yielded a hazard ratio (HR) of 0.98 [95 % CI 0.89–1.09]). The overall risk of incident type 1 diabetes was low and yielded a HR of 1.60 [95 % CI 0.98–1.40] in patients with MS compared with control subject (P = 0.07). Conclusion: This study demonstrated that patients with MS had a similar risk of incident DM as compared to age- and sex matched controls from the background population.
KW - Diabetes mellitus
KW - Disease association
KW - Disease prevention
KW - Epidemiology
U2 - 10.1016/j.diabet.2024.101551
DO - 10.1016/j.diabet.2024.101551
M3 - Journal article
C2 - 38914221
AN - SCOPUS:85196838901
VL - 50
JO - Diabetes & Metabolism
JF - Diabetes & Metabolism
SN - 1262-3636
IS - 5
M1 - 101551
ER -
ID: 396943704