Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest. / Nilsson, Frederik Nancke; Bie-Bogh, Søren; Milling, Louise; Hansen, Peter Martin; Pedersen, Helena; Christensen, Erika F.; Knudsen, Jens Stubager; Christensen, Helle Collatz; Folke, Fredrik; Høen-Beck, David; Væggemose, Ulla; Brøchner, Anne Craveiro; Mikkelsen, Søren.

In: Scientific Reports, Vol. 13, No. 1, 20796, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nilsson, FN, Bie-Bogh, S, Milling, L, Hansen, PM, Pedersen, H, Christensen, EF, Knudsen, JS, Christensen, HC, Folke, F, Høen-Beck, D, Væggemose, U, Brøchner, AC & Mikkelsen, S 2023, 'Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest', Scientific Reports, vol. 13, no. 1, 20796. https://doi.org/10.1038/s41598-023-48350-8

APA

Nilsson, F. N., Bie-Bogh, S., Milling, L., Hansen, P. M., Pedersen, H., Christensen, E. F., Knudsen, J. S., Christensen, H. C., Folke, F., Høen-Beck, D., Væggemose, U., Brøchner, A. C., & Mikkelsen, S. (2023). Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest. Scientific Reports, 13(1), [20796]. https://doi.org/10.1038/s41598-023-48350-8

Vancouver

Nilsson FN, Bie-Bogh S, Milling L, Hansen PM, Pedersen H, Christensen EF et al. Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest. Scientific Reports. 2023;13(1). 20796. https://doi.org/10.1038/s41598-023-48350-8

Author

Nilsson, Frederik Nancke ; Bie-Bogh, Søren ; Milling, Louise ; Hansen, Peter Martin ; Pedersen, Helena ; Christensen, Erika F. ; Knudsen, Jens Stubager ; Christensen, Helle Collatz ; Folke, Fredrik ; Høen-Beck, David ; Væggemose, Ulla ; Brøchner, Anne Craveiro ; Mikkelsen, Søren. / Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest. In: Scientific Reports. 2023 ; Vol. 13, No. 1.

Bibtex

@article{e476b44788a64a46a057b90e0c813af1,

title = "Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest",

abstract = "Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest. Intraosseous drug delivery is considered an alternative option in resuscitation if intravenous access is difficult or impossible. Intraosseous uptake of drugs may, however, be compromised. We have performed a retrospective cohort study of all Danish patients with out-of-hospital cardiac arrest in the years 2016–2020 to investigate whether mortality is associated with the route of drug delivery. Outcome was 30-day mortality, death at the scene, no prehospital return of spontaneous circulation, and 7- and 90-days mortality. 17,250 patients had out-of-hospital cardiac arrest. 6243 patients received no treatment and were excluded. 1908 patients had sustained return of spontaneous circulation before access to the vascular bed was obtained. 2061 patients were unidentified, and 286 cases were erroneously registered. Thus, this report consist of results from 6752 patients. Drug delivery by intraosseous route is associated with increased OR of: No spontaneous circulation at any time (OR 1.51), Death at 7 days (OR 1.94), 30 days (2.02), and 90 days (OR 2.29). Intraosseous drug delivery in out-of-hospital cardiac arrest is associated with overall poorer outcomes than intravenous drug delivery.",

author = "Nilsson, {Frederik Nancke} and S{\o}ren Bie-Bogh and Louise Milling and Hansen, {Peter Martin} and Helena Pedersen and Christensen, {Erika F.} and Knudsen, {Jens Stubager} and Christensen, {Helle Collatz} and Fredrik Folke and David H{\o}en-Beck and Ulla V{\ae}ggemose and Br{\o}chner, {Anne Craveiro} and S{\o}ren Mikkelsen",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

doi = "10.1038/s41598-023-48350-8",

language = "English",

volume = "13",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest

AU - Nilsson, Frederik Nancke

AU - Bie-Bogh, Søren

AU - Milling, Louise

AU - Hansen, Peter Martin

AU - Pedersen, Helena

AU - Christensen, Erika F.

AU - Knudsen, Jens Stubager

AU - Christensen, Helle Collatz

AU - Folke, Fredrik

AU - Høen-Beck, David

AU - Væggemose, Ulla

AU - Brøchner, Anne Craveiro

AU - Mikkelsen, Søren

PY - 2023

Y1 - 2023

N2 - Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest. Intraosseous drug delivery is considered an alternative option in resuscitation if intravenous access is difficult or impossible. Intraosseous uptake of drugs may, however, be compromised. We have performed a retrospective cohort study of all Danish patients with out-of-hospital cardiac arrest in the years 2016–2020 to investigate whether mortality is associated with the route of drug delivery. Outcome was 30-day mortality, death at the scene, no prehospital return of spontaneous circulation, and 7- and 90-days mortality. 17,250 patients had out-of-hospital cardiac arrest. 6243 patients received no treatment and were excluded. 1908 patients had sustained return of spontaneous circulation before access to the vascular bed was obtained. 2061 patients were unidentified, and 286 cases were erroneously registered. Thus, this report consist of results from 6752 patients. Drug delivery by intraosseous route is associated with increased OR of: No spontaneous circulation at any time (OR 1.51), Death at 7 days (OR 1.94), 30 days (2.02), and 90 days (OR 2.29). Intraosseous drug delivery in out-of-hospital cardiac arrest is associated with overall poorer outcomes than intravenous drug delivery.

AB - Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest. Intraosseous drug delivery is considered an alternative option in resuscitation if intravenous access is difficult or impossible. Intraosseous uptake of drugs may, however, be compromised. We have performed a retrospective cohort study of all Danish patients with out-of-hospital cardiac arrest in the years 2016–2020 to investigate whether mortality is associated with the route of drug delivery. Outcome was 30-day mortality, death at the scene, no prehospital return of spontaneous circulation, and 7- and 90-days mortality. 17,250 patients had out-of-hospital cardiac arrest. 6243 patients received no treatment and were excluded. 1908 patients had sustained return of spontaneous circulation before access to the vascular bed was obtained. 2061 patients were unidentified, and 286 cases were erroneously registered. Thus, this report consist of results from 6752 patients. Drug delivery by intraosseous route is associated with increased OR of: No spontaneous circulation at any time (OR 1.51), Death at 7 days (OR 1.94), 30 days (2.02), and 90 days (OR 2.29). Intraosseous drug delivery in out-of-hospital cardiac arrest is associated with overall poorer outcomes than intravenous drug delivery.

U2 - 10.1038/s41598-023-48350-8

DO - 10.1038/s41598-023-48350-8

M3 - Journal article

C2 - 38012312

AN - SCOPUS:85177820679

VL - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 20796

ER -

ID: 375875181

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