Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia
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Association of anthropometry and weight change with risk of dementia and its major subtypes : A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia. / Lee, Crystal Man Ying; Woodward, Mark; Batty, G. David; Beiser, Alexa S.; Bell, Steven; Berr, Claudine; Bjertness, Espen; Chalmers, John; Clarke, Robert; Dartigues, Jean Francois; Davis-Plourde, Kendra; Debette, Stéphanie; Di Angelantonio, Emanuele; Feart, Catherine; Frikke-Schmidt, Ruth; Gregson, John; Haan, Mary N.; Hassing, Linda B.; Hayden, Kathleen M.; Hoevenaar-Blom, Marieke P.; Kaprio, Jaakko; Kivimaki, Mika; Lappas, Georgios; Larson, Eric B.; LeBlanc, Erin S.; Lee, Anne; Lui, Li Yung; Moll van Charante, Eric P.; Ninomiya, Toshiharu; Nordestgaard, Liv Tybjærg; Ohara, Tomoyuki; Ohkuma, Toshiaki; Palviainen, Teemu; Peres, Karine; Peters, Ruth; Qizilbash, Nawab; Richard, Edo; Rosengren, Annika; Seshadri, Sudha; Shipley, Martin; Singh-Manoux, Archana; Strand, Bjorn Heine; van Gool, Willem A.; Vuoksimaa, Eero; Yaffe, Kristine; Huxley, Rachel R.
In: Obesity Reviews, Vol. 21, No. 4, e12989, 04.2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association of anthropometry and weight change with risk of dementia and its major subtypes
T2 - A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia
AU - Lee, Crystal Man Ying
AU - Woodward, Mark
AU - Batty, G. David
AU - Beiser, Alexa S.
AU - Bell, Steven
AU - Berr, Claudine
AU - Bjertness, Espen
AU - Chalmers, John
AU - Clarke, Robert
AU - Dartigues, Jean Francois
AU - Davis-Plourde, Kendra
AU - Debette, Stéphanie
AU - Di Angelantonio, Emanuele
AU - Feart, Catherine
AU - Frikke-Schmidt, Ruth
AU - Gregson, John
AU - Haan, Mary N.
AU - Hassing, Linda B.
AU - Hayden, Kathleen M.
AU - Hoevenaar-Blom, Marieke P.
AU - Kaprio, Jaakko
AU - Kivimaki, Mika
AU - Lappas, Georgios
AU - Larson, Eric B.
AU - LeBlanc, Erin S.
AU - Lee, Anne
AU - Lui, Li Yung
AU - Moll van Charante, Eric P.
AU - Ninomiya, Toshiharu
AU - Nordestgaard, Liv Tybjærg
AU - Ohara, Tomoyuki
AU - Ohkuma, Toshiaki
AU - Palviainen, Teemu
AU - Peres, Karine
AU - Peters, Ruth
AU - Qizilbash, Nawab
AU - Richard, Edo
AU - Rosengren, Annika
AU - Seshadri, Sudha
AU - Shipley, Martin
AU - Singh-Manoux, Archana
AU - Strand, Bjorn Heine
AU - van Gool, Willem A.
AU - Vuoksimaa, Eero
AU - Yaffe, Kristine
AU - Huxley, Rachel R.
PY - 2020/4
Y1 - 2020/4
N2 - Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index–defined lower-normal weight (18.5-22.4 kg/m2), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5-24.9 kg/m2) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had nonsignificant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change, and dementia is complex and exhibits non-linear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.
AB - Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index–defined lower-normal weight (18.5-22.4 kg/m2), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5-24.9 kg/m2) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had nonsignificant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change, and dementia is complex and exhibits non-linear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.
U2 - 10.1111/obr.12989
DO - 10.1111/obr.12989
M3 - Journal article
C2 - 31898862
AN - SCOPUS:85077848803
VL - 21
JO - Obesity Reviews
JF - Obesity Reviews
SN - 1467-7881
IS - 4
M1 - e12989
ER -
ID: 243111287