Assessment of Liver Fat: Dual-Energy CT versus Conventional CT with and without Contrast
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Assessment of Liver Fat : Dual-Energy CT versus Conventional CT with and without Contrast. / Xu, Jack Junchi; Boesen, Mikkel Ranum; Hansen, Sofie Lindskov; Ulriksen, Peter Sommer; Holm, Soren; Lonn, Lars; Hansen, Kristoffer Lindskov.
In: Diagnostics, Vol. 12, No. 3, 708, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Assessment of Liver Fat
T2 - Dual-Energy CT versus Conventional CT with and without Contrast
AU - Xu, Jack Junchi
AU - Boesen, Mikkel Ranum
AU - Hansen, Sofie Lindskov
AU - Ulriksen, Peter Sommer
AU - Holm, Soren
AU - Lonn, Lars
AU - Hansen, Kristoffer Lindskov
PY - 2022
Y1 - 2022
N2 - We assessed the correlation between liver fat percentage using dual-energy CT (DECT) and Hounsfield unit (HU) measurements in contrast and non-contrast CT. This study included 177 patients in two patient groups: Group A (n = 125) underwent whole body non-contrast DECT and group B (n = 52) had a multiphasic DECT including a conventional non-contrast CT. Three regions of interest were placed on each image series, one in the left liver lobe and two in the right to measure Hounsfield Units (HU) as well as liver fat percentage. Linear regression analysis was performed for each group as well as combined. Receiver operating characteristic (ROC) curve was generated to establish the optimal fat percentage threshold value in DECT for predicting a non-contrast threshold of 40 HU correlating to moderate-severe liver steatosis. We found a strong correlation between fat percentage found with DECT and HU measured in non-contrast CT in group A and B individually (R-2 = 0.81 and 0.86, respectively) as well as combined (R-2 = 0.85). No significant difference was found when comparing venous and arterial phase DECT fat percentage measurements in group B (p = 0.67). A threshold of 10% liver fat found with DECT had 95% sensitivity and 95% specificity for the prediction of a 40 HU threshold using non-contrast CT. In conclusion, liver fat quantification using DECT shows high correlation with HU measurements independent of scan phase.
AB - We assessed the correlation between liver fat percentage using dual-energy CT (DECT) and Hounsfield unit (HU) measurements in contrast and non-contrast CT. This study included 177 patients in two patient groups: Group A (n = 125) underwent whole body non-contrast DECT and group B (n = 52) had a multiphasic DECT including a conventional non-contrast CT. Three regions of interest were placed on each image series, one in the left liver lobe and two in the right to measure Hounsfield Units (HU) as well as liver fat percentage. Linear regression analysis was performed for each group as well as combined. Receiver operating characteristic (ROC) curve was generated to establish the optimal fat percentage threshold value in DECT for predicting a non-contrast threshold of 40 HU correlating to moderate-severe liver steatosis. We found a strong correlation between fat percentage found with DECT and HU measured in non-contrast CT in group A and B individually (R-2 = 0.81 and 0.86, respectively) as well as combined (R-2 = 0.85). No significant difference was found when comparing venous and arterial phase DECT fat percentage measurements in group B (p = 0.67). A threshold of 10% liver fat found with DECT had 95% sensitivity and 95% specificity for the prediction of a 40 HU threshold using non-contrast CT. In conclusion, liver fat quantification using DECT shows high correlation with HU measurements independent of scan phase.
KW - liver fat quantification
KW - dual-energy CT
KW - spectral CT
KW - HEPATIC STEATOSIS
KW - COMPUTED-TOMOGRAPHY
KW - QUANTIFICATION
KW - FRACTION
KW - DISEASE
KW - ADULTS
KW - DECOMPOSITION
KW - DIAGNOSIS
U2 - 10.3390/diagnostics12030708
DO - 10.3390/diagnostics12030708
M3 - Journal article
C2 - 35328261
VL - 12
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 3
M1 - 708
ER -
ID: 308048139