Assessment of in vivo MR imaging compared to physical sections in vitro-A quantitative study of brain volumes using stereology.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Assessment of in vivo MR imaging compared to physical sections in vitro-A quantitative study of brain volumes using stereology. / Jelsing, Jacob; Rostrup, Egill; Markenroth, Karin; Paulson, Olaf B.; Gundersen, Hans Jørgen G; Hemmingsen, Ralf; Pakkenberg, Bente.

In: NeuroImage, Vol. 26, No. 1, 2005, p. 57-65.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jelsing, J, Rostrup, E, Markenroth, K, Paulson, OB, Gundersen, HJG, Hemmingsen, R & Pakkenberg, B 2005, 'Assessment of in vivo MR imaging compared to physical sections in vitro-A quantitative study of brain volumes using stereology.', NeuroImage, vol. 26, no. 1, pp. 57-65. <http://www.ncbi.nlm.nih.gov//entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15862205>

APA

Jelsing, J., Rostrup, E., Markenroth, K., Paulson, O. B., Gundersen, H. J. G., Hemmingsen, R., & Pakkenberg, B. (2005). Assessment of in vivo MR imaging compared to physical sections in vitro-A quantitative study of brain volumes using stereology. NeuroImage, 26(1), 57-65. http://www.ncbi.nlm.nih.gov//entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15862205

Vancouver

Jelsing J, Rostrup E, Markenroth K, Paulson OB, Gundersen HJG, Hemmingsen R et al. Assessment of in vivo MR imaging compared to physical sections in vitro-A quantitative study of brain volumes using stereology. NeuroImage. 2005;26(1):57-65.

Author

Jelsing, Jacob ; Rostrup, Egill ; Markenroth, Karin ; Paulson, Olaf B. ; Gundersen, Hans Jørgen G ; Hemmingsen, Ralf ; Pakkenberg, Bente. / Assessment of in vivo MR imaging compared to physical sections in vitro-A quantitative study of brain volumes using stereology. In: NeuroImage. 2005 ; Vol. 26, No. 1. pp. 57-65.

Bibtex

@article{a3e06a55c4a24d1780f7f6be4b7a7d9d,
title = "Assessment of in vivo MR imaging compared to physical sections in vitro-A quantitative study of brain volumes using stereology.",
abstract = "The object of the present study was to compare stereological estimates of brain volumes obtained in vivo by magnetic resonance imaging (MRI) to corresponding volumes from physical sections in vitro. Brains of ten domestic pigs were imaged using a 3-T scanner. The volumes of different brain compartments were obtained from MR images by two observers and from physical sections using the Cavalieri estimator in combination with point counting. Paired t tests revealed no significant differences between the two methods for any of the five compartments considered, except for the basal gray compartment. However, although intraobserver difference of MRI estimates was acceptable, the interobserver difference was not. A statistical highly significant difference of 11-41% was observed between observers for volume estimates of all compartments considered. The study demonstrates that quantitative MRI is susceptible to observer dependent interpretation of images",
author = "Jacob Jelsing and Egill Rostrup and Karin Markenroth and Paulson, {Olaf B.} and Gundersen, {Hans J{\o}rgen G} and Ralf Hemmingsen and Bente Pakkenberg",
year = "2005",
language = "English",
volume = "26",
pages = "57--65",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Assessment of in vivo MR imaging compared to physical sections in vitro-A quantitative study of brain volumes using stereology.

AU - Jelsing, Jacob

AU - Rostrup, Egill

AU - Markenroth, Karin

AU - Paulson, Olaf B.

AU - Gundersen, Hans Jørgen G

AU - Hemmingsen, Ralf

AU - Pakkenberg, Bente

PY - 2005

Y1 - 2005

N2 - The object of the present study was to compare stereological estimates of brain volumes obtained in vivo by magnetic resonance imaging (MRI) to corresponding volumes from physical sections in vitro. Brains of ten domestic pigs were imaged using a 3-T scanner. The volumes of different brain compartments were obtained from MR images by two observers and from physical sections using the Cavalieri estimator in combination with point counting. Paired t tests revealed no significant differences between the two methods for any of the five compartments considered, except for the basal gray compartment. However, although intraobserver difference of MRI estimates was acceptable, the interobserver difference was not. A statistical highly significant difference of 11-41% was observed between observers for volume estimates of all compartments considered. The study demonstrates that quantitative MRI is susceptible to observer dependent interpretation of images

AB - The object of the present study was to compare stereological estimates of brain volumes obtained in vivo by magnetic resonance imaging (MRI) to corresponding volumes from physical sections in vitro. Brains of ten domestic pigs were imaged using a 3-T scanner. The volumes of different brain compartments were obtained from MR images by two observers and from physical sections using the Cavalieri estimator in combination with point counting. Paired t tests revealed no significant differences between the two methods for any of the five compartments considered, except for the basal gray compartment. However, although intraobserver difference of MRI estimates was acceptable, the interobserver difference was not. A statistical highly significant difference of 11-41% was observed between observers for volume estimates of all compartments considered. The study demonstrates that quantitative MRI is susceptible to observer dependent interpretation of images

M3 - Journal article

VL - 26

SP - 57

EP - 65

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 1

ER -

ID: 34057811