Anthracycline extravasation: a comprehensive review of experimental and clinical treatments
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Anthracycline extravasation : a comprehensive review of experimental and clinical treatments. / Langer, Seppo W; Sehested, Maxwell; Jensen, Peter Buhl.
In: Tumori, Vol. 95, No. 3, 20.08.2009, p. 273-82.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Anthracycline extravasation
T2 - a comprehensive review of experimental and clinical treatments
AU - Langer, Seppo W
AU - Sehested, Maxwell
AU - Jensen, Peter Buhl
PY - 2009/8/20
Y1 - 2009/8/20
N2 - An accidental extravasation of anthracycline-containing chemotherapy is a feared complication that may lead to necrosis and severe tissue destruction. For four decades, much effort has been done to prevent and treat this devastating condition. Savene has recently been proved to be very effective, and is the only approved treatment against anthracyline extravasation. It is thus now widely recommended. The present article represents a comprehensive review of, and historical insight to, the experimental and clinical studies of surgical and non-surgical treatments of extravasation during forty years of clinical anthracycline treatment.
AB - An accidental extravasation of anthracycline-containing chemotherapy is a feared complication that may lead to necrosis and severe tissue destruction. For four decades, much effort has been done to prevent and treat this devastating condition. Savene has recently been proved to be very effective, and is the only approved treatment against anthracyline extravasation. It is thus now widely recommended. The present article represents a comprehensive review of, and historical insight to, the experimental and clinical studies of surgical and non-surgical treatments of extravasation during forty years of clinical anthracycline treatment.
KW - Adrenal Cortex Hormones/therapeutic use
KW - Animals
KW - Anthracyclines/administration & dosage
KW - Antibiotics, Antineoplastic/administration & dosage
KW - Bicarbonates/therapeutic use
KW - Dimethyl Sulfoxide/therapeutic use
KW - Extravasation of Diagnostic and Therapeutic Materials/drug therapy
KW - Fibroblast Growth Factor 2/therapeutic use
KW - Granulocyte Colony-Stimulating Factor/therapeutic use
KW - Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use
KW - Humans
KW - Hyaluronoglucosaminidase/therapeutic use
KW - Necrosis/chemically induced
KW - Razoxane/therapeutic use
KW - Skin Diseases/chemically induced
KW - Ulcer/chemically induced
KW - alpha-Tocopherol/therapeutic use
M3 - Review
C2 - 19688963
VL - 95
SP - 273
EP - 282
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 3
ER -
ID: 247891329