Animal models for cystic fibrosis: A systematic search and mapping review of the literature – Part 1: genetic models

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Animal models for cystic fibrosis : A systematic search and mapping review of the literature – Part 1: genetic models. / Leenaars, Cathalijn H.C.; De Vries, Rob B.M.; Heming, Anna; Visser, Damian; Holthaus, David; Reijmer, Joey; Elzinga, Janneke; Kempkes, Rosalie W.M.; Punt, Carine; Beumer, Wouter; Meijboom, Franck L.B.; Ritskes-Hoitinga, Merel.

In: Laboratory Animals, Vol. 54, No. 4, 2020, p. 330-340.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Leenaars, CHC, De Vries, RBM, Heming, A, Visser, D, Holthaus, D, Reijmer, J, Elzinga, J, Kempkes, RWM, Punt, C, Beumer, W, Meijboom, FLB & Ritskes-Hoitinga, M 2020, 'Animal models for cystic fibrosis: A systematic search and mapping review of the literature – Part 1: genetic models', Laboratory Animals, vol. 54, no. 4, pp. 330-340. https://doi.org/10.1177/0023677219868502

APA

Leenaars, C. H. C., De Vries, R. B. M., Heming, A., Visser, D., Holthaus, D., Reijmer, J., Elzinga, J., Kempkes, R. W. M., Punt, C., Beumer, W., Meijboom, F. L. B., & Ritskes-Hoitinga, M. (2020). Animal models for cystic fibrosis: A systematic search and mapping review of the literature – Part 1: genetic models. Laboratory Animals, 54(4), 330-340. https://doi.org/10.1177/0023677219868502

Vancouver

Leenaars CHC, De Vries RBM, Heming A, Visser D, Holthaus D, Reijmer J et al. Animal models for cystic fibrosis: A systematic search and mapping review of the literature – Part 1: genetic models. Laboratory Animals. 2020;54(4):330-340. https://doi.org/10.1177/0023677219868502

Author

Leenaars, Cathalijn H.C. ; De Vries, Rob B.M. ; Heming, Anna ; Visser, Damian ; Holthaus, David ; Reijmer, Joey ; Elzinga, Janneke ; Kempkes, Rosalie W.M. ; Punt, Carine ; Beumer, Wouter ; Meijboom, Franck L.B. ; Ritskes-Hoitinga, Merel. / Animal models for cystic fibrosis : A systematic search and mapping review of the literature – Part 1: genetic models. In: Laboratory Animals. 2020 ; Vol. 54, No. 4. pp. 330-340.

Bibtex

@article{abce7d06ae4a429a9832de9cf5253975,
title = "Animal models for cystic fibrosis: A systematic search and mapping review of the literature – Part 1: genetic models",
abstract = "Animal models for cystic fibrosis (CF) have enhanced our understanding of the pathology and contributed to the development of new treatments. In the field of CF, many animal models have been developed and described. To our knowledge, thus far, none of the reviews of CF animal models has used a systematic methodology. A systematic approach to creating model overviews can lead to an objective, evidence-based choice of an animal model for new research questions. We searched Pubmed and Embase for the currently available animal models for CF. Two independent reviewers screened the results. We included all primary studies describing an animal model for CF. After duplicate removal, 12,304 publications were left. Because of the large number of models, in the current paper, only the genetic models are presented. A total of 636 publications were identified describing genetic animal models for CF in mice, pigs, ferrets, rats and zebrafish. Most of these models have an altered Cftr gene. An overview of basic model characteristics and outcome measures for these genetic models is provided, together with advice on using these data. As far as the authors are aware, this is one of the largest systematic mapping reviews on genetic animal models for CF. It can aid in selecting a suitable model and outcome measures. In general, the reporting quality of the included publications was poor. Further systematic reviews are warranted to determine the quality and translational value of these models further.",
keywords = "Animal models, cystic fibrosis, outcome measures, search string, systematic map",
author = "Leenaars, {Cathalijn H.C.} and {De Vries}, {Rob B.M.} and Anna Heming and Damian Visser and David Holthaus and Joey Reijmer and Janneke Elzinga and Kempkes, {Rosalie W.M.} and Carine Punt and Wouter Beumer and Meijboom, {Franck L.B.} and Merel Ritskes-Hoitinga",
note = "Funding Information: The authors would like to acknowledge Alice Tillema (information specialist), Peter Mercus (clinician) and an anonymous patient for reviewing our protocol, and the anonymous patient for reviewing a draft of this publication. Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by NWO (grant number 313-99-310), R2N, Federal State of Lower Saxony and the DFG (grant number FOR2591, BL 953/11-1). Publisher Copyright: {\textcopyright} The Author(s) 2019.",
year = "2020",
doi = "10.1177/0023677219868502",
language = "English",
volume = "54",
pages = "330--340",
journal = "Laboratory Animals",
issn = "0023-6772",
publisher = "SAGE Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Animal models for cystic fibrosis

T2 - A systematic search and mapping review of the literature – Part 1: genetic models

AU - Leenaars, Cathalijn H.C.

AU - De Vries, Rob B.M.

AU - Heming, Anna

AU - Visser, Damian

AU - Holthaus, David

AU - Reijmer, Joey

AU - Elzinga, Janneke

AU - Kempkes, Rosalie W.M.

AU - Punt, Carine

AU - Beumer, Wouter

AU - Meijboom, Franck L.B.

AU - Ritskes-Hoitinga, Merel

N1 - Funding Information: The authors would like to acknowledge Alice Tillema (information specialist), Peter Mercus (clinician) and an anonymous patient for reviewing our protocol, and the anonymous patient for reviewing a draft of this publication. Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by NWO (grant number 313-99-310), R2N, Federal State of Lower Saxony and the DFG (grant number FOR2591, BL 953/11-1). Publisher Copyright: © The Author(s) 2019.

PY - 2020

Y1 - 2020

N2 - Animal models for cystic fibrosis (CF) have enhanced our understanding of the pathology and contributed to the development of new treatments. In the field of CF, many animal models have been developed and described. To our knowledge, thus far, none of the reviews of CF animal models has used a systematic methodology. A systematic approach to creating model overviews can lead to an objective, evidence-based choice of an animal model for new research questions. We searched Pubmed and Embase for the currently available animal models for CF. Two independent reviewers screened the results. We included all primary studies describing an animal model for CF. After duplicate removal, 12,304 publications were left. Because of the large number of models, in the current paper, only the genetic models are presented. A total of 636 publications were identified describing genetic animal models for CF in mice, pigs, ferrets, rats and zebrafish. Most of these models have an altered Cftr gene. An overview of basic model characteristics and outcome measures for these genetic models is provided, together with advice on using these data. As far as the authors are aware, this is one of the largest systematic mapping reviews on genetic animal models for CF. It can aid in selecting a suitable model and outcome measures. In general, the reporting quality of the included publications was poor. Further systematic reviews are warranted to determine the quality and translational value of these models further.

AB - Animal models for cystic fibrosis (CF) have enhanced our understanding of the pathology and contributed to the development of new treatments. In the field of CF, many animal models have been developed and described. To our knowledge, thus far, none of the reviews of CF animal models has used a systematic methodology. A systematic approach to creating model overviews can lead to an objective, evidence-based choice of an animal model for new research questions. We searched Pubmed and Embase for the currently available animal models for CF. Two independent reviewers screened the results. We included all primary studies describing an animal model for CF. After duplicate removal, 12,304 publications were left. Because of the large number of models, in the current paper, only the genetic models are presented. A total of 636 publications were identified describing genetic animal models for CF in mice, pigs, ferrets, rats and zebrafish. Most of these models have an altered Cftr gene. An overview of basic model characteristics and outcome measures for these genetic models is provided, together with advice on using these data. As far as the authors are aware, this is one of the largest systematic mapping reviews on genetic animal models for CF. It can aid in selecting a suitable model and outcome measures. In general, the reporting quality of the included publications was poor. Further systematic reviews are warranted to determine the quality and translational value of these models further.

KW - Animal models

KW - cystic fibrosis

KW - outcome measures

KW - search string

KW - systematic map

U2 - 10.1177/0023677219868502

DO - 10.1177/0023677219868502

M3 - Review

C2 - 31411127

AN - SCOPUS:85071459579

VL - 54

SP - 330

EP - 340

JO - Laboratory Animals

JF - Laboratory Animals

SN - 0023-6772

IS - 4

ER -

ID: 359858905