Animal models for cystic fibrosis: a systematic search and mapping review of the literature. Part 2: nongenetic models

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Animal models for cystic fibrosis : a systematic search and mapping review of the literature. Part 2: nongenetic models. / Leenaars, Cathalijn H.C.; Vries, Rob BM de; Reijmer, Joey; Holthaus, David; Visser, Damian; Heming, Anna; Elzinga, Janneke; Kempkes, Rosalie W.M.; Beumer, Wouter; Punt, Carine; Meijboom, Franck L.B.; Ritskes-Hoitinga, Merel.

In: Laboratory Animals, Vol. 55, No. 4, 2021, p. 307-316.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Leenaars, CHC, Vries, RBMD, Reijmer, J, Holthaus, D, Visser, D, Heming, A, Elzinga, J, Kempkes, RWM, Beumer, W, Punt, C, Meijboom, FLB & Ritskes-Hoitinga, M 2021, 'Animal models for cystic fibrosis: a systematic search and mapping review of the literature. Part 2: nongenetic models', Laboratory Animals, vol. 55, no. 4, pp. 307-316. https://doi.org/10.1177/0023677221990688

APA

Leenaars, C. H. C., Vries, R. BM. D., Reijmer, J., Holthaus, D., Visser, D., Heming, A., Elzinga, J., Kempkes, R. W. M., Beumer, W., Punt, C., Meijboom, F. L. B., & Ritskes-Hoitinga, M. (2021). Animal models for cystic fibrosis: a systematic search and mapping review of the literature. Part 2: nongenetic models. Laboratory Animals, 55(4), 307-316. https://doi.org/10.1177/0023677221990688

Vancouver

Leenaars CHC, Vries RBMD, Reijmer J, Holthaus D, Visser D, Heming A et al. Animal models for cystic fibrosis: a systematic search and mapping review of the literature. Part 2: nongenetic models. Laboratory Animals. 2021;55(4):307-316. https://doi.org/10.1177/0023677221990688

Author

Leenaars, Cathalijn H.C. ; Vries, Rob BM de ; Reijmer, Joey ; Holthaus, David ; Visser, Damian ; Heming, Anna ; Elzinga, Janneke ; Kempkes, Rosalie W.M. ; Beumer, Wouter ; Punt, Carine ; Meijboom, Franck L.B. ; Ritskes-Hoitinga, Merel. / Animal models for cystic fibrosis : a systematic search and mapping review of the literature. Part 2: nongenetic models. In: Laboratory Animals. 2021 ; Vol. 55, No. 4. pp. 307-316.

Bibtex

@article{29645c3da75140e1922b39aba5b29508,
title = "Animal models for cystic fibrosis: a systematic search and mapping review of the literature. Part 2: nongenetic models",
abstract = "Various animal models are available to study cystic fibrosis (CF). These models may help to enhance our understanding of the pathology and contribute to the development of new treatments. We systematically searched all publications on CF animal models. Because of the large number of models retrieved, we split this mapping review into two parts. Previously, we presented the genetic CF animal models. In this paper we present the nongenetic CF animal models. While genetic animal models may, in theory, be preferable for genetic diseases, the phenotype of a genetic model does not automatically resemble human disease. Depending on the research question, other animal models may thus be more informative. We searched Pubmed and Embase and identified 12,303 unique publications (after duplicate removal). All references were screened for inclusion by two independent reviewers. The genetic animal models for CF (from 636 publications) were previously described. The non-genetic CF models (from 189 publications) are described in this paper, grouped by model type: infection-based, pharmacological, administration of human materials, xenografts and other. As before for the genetic models, an overview of basic model characteristics and outcome measures is provided. This CF animal model overview can be the basis for an objective, evidence-based model choice for specific research questions. Besides, it can help to retrieve relevant background literature on outcome measures of interest.",
keywords = "Animal models, cystic fibrosis, outcome measures, search string, systematic map",
author = "Leenaars, {Cathalijn H.C.} and Vries, {Rob BM de} and Joey Reijmer and David Holthaus and Damian Visser and Anna Heming and Janneke Elzinga and Kempkes, {Rosalie W.M.} and Wouter Beumer and Carine Punt and Meijboom, {Franck L.B.} and Merel Ritskes-Hoitinga",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by NWO [grant number 313-99-310], R2N, Federal State of Lower Saxony, and the DFG [grant number FOR2591, BL 953/11-2]. Funding Information: The authors would like to acknowledge Alice Tillema (information specialist) and Peter Mercus (clinician) for reviewing our protocol. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by NWO [grant number 313-99-310], R2N, Federal State of Lower Saxony, and the DFG [grant number FOR2591, BL 953/11-2]. Publisher Copyright: {\textcopyright} The Author(s) 2021.",
year = "2021",
doi = "10.1177/0023677221990688",
language = "English",
volume = "55",
pages = "307--316",
journal = "Laboratory Animals",
issn = "0023-6772",
publisher = "SAGE Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Animal models for cystic fibrosis

T2 - a systematic search and mapping review of the literature. Part 2: nongenetic models

AU - Leenaars, Cathalijn H.C.

AU - Vries, Rob BM de

AU - Reijmer, Joey

AU - Holthaus, David

AU - Visser, Damian

AU - Heming, Anna

AU - Elzinga, Janneke

AU - Kempkes, Rosalie W.M.

AU - Beumer, Wouter

AU - Punt, Carine

AU - Meijboom, Franck L.B.

AU - Ritskes-Hoitinga, Merel

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by NWO [grant number 313-99-310], R2N, Federal State of Lower Saxony, and the DFG [grant number FOR2591, BL 953/11-2]. Funding Information: The authors would like to acknowledge Alice Tillema (information specialist) and Peter Mercus (clinician) for reviewing our protocol. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by NWO [grant number 313-99-310], R2N, Federal State of Lower Saxony, and the DFG [grant number FOR2591, BL 953/11-2]. Publisher Copyright: © The Author(s) 2021.

PY - 2021

Y1 - 2021

N2 - Various animal models are available to study cystic fibrosis (CF). These models may help to enhance our understanding of the pathology and contribute to the development of new treatments. We systematically searched all publications on CF animal models. Because of the large number of models retrieved, we split this mapping review into two parts. Previously, we presented the genetic CF animal models. In this paper we present the nongenetic CF animal models. While genetic animal models may, in theory, be preferable for genetic diseases, the phenotype of a genetic model does not automatically resemble human disease. Depending on the research question, other animal models may thus be more informative. We searched Pubmed and Embase and identified 12,303 unique publications (after duplicate removal). All references were screened for inclusion by two independent reviewers. The genetic animal models for CF (from 636 publications) were previously described. The non-genetic CF models (from 189 publications) are described in this paper, grouped by model type: infection-based, pharmacological, administration of human materials, xenografts and other. As before for the genetic models, an overview of basic model characteristics and outcome measures is provided. This CF animal model overview can be the basis for an objective, evidence-based model choice for specific research questions. Besides, it can help to retrieve relevant background literature on outcome measures of interest.

AB - Various animal models are available to study cystic fibrosis (CF). These models may help to enhance our understanding of the pathology and contribute to the development of new treatments. We systematically searched all publications on CF animal models. Because of the large number of models retrieved, we split this mapping review into two parts. Previously, we presented the genetic CF animal models. In this paper we present the nongenetic CF animal models. While genetic animal models may, in theory, be preferable for genetic diseases, the phenotype of a genetic model does not automatically resemble human disease. Depending on the research question, other animal models may thus be more informative. We searched Pubmed and Embase and identified 12,303 unique publications (after duplicate removal). All references were screened for inclusion by two independent reviewers. The genetic animal models for CF (from 636 publications) were previously described. The non-genetic CF models (from 189 publications) are described in this paper, grouped by model type: infection-based, pharmacological, administration of human materials, xenografts and other. As before for the genetic models, an overview of basic model characteristics and outcome measures is provided. This CF animal model overview can be the basis for an objective, evidence-based model choice for specific research questions. Besides, it can help to retrieve relevant background literature on outcome measures of interest.

KW - Animal models

KW - cystic fibrosis

KW - outcome measures

KW - search string

KW - systematic map

U2 - 10.1177/0023677221990688

DO - 10.1177/0023677221990688

M3 - Review

C2 - 33557683

AN - SCOPUS:85101001825

VL - 55

SP - 307

EP - 316

JO - Laboratory Animals

JF - Laboratory Animals

SN - 0023-6772

IS - 4

ER -

ID: 359858664