Ancient Metagenomic Studies: Considerations for the Wider Scientific Community
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Ancient Metagenomic Studies : Considerations for the Wider Scientific Community. / Der Sarkissian, Clio; Velsko, Irina M.; Fotakis, Anna K.; Vågene, Åshild J.; Hübner, Alexander; Yates, James A. Fellows.
In: mSystems, Vol. 6, No. 6, e01315-21, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Ancient Metagenomic Studies
T2 - Considerations for the Wider Scientific Community
AU - Der Sarkissian, Clio
AU - Velsko, Irina M.
AU - Fotakis, Anna K.
AU - Vågene, Åshild J.
AU - Hübner, Alexander
AU - Yates, James A. Fellows
N1 - Publisher Copyright: © 2021 American Society for Microbiology. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Like modern metagenomics, ancient metagenomics is a highly data-rich discipline, with the added challenge that the DNA of interest is degraded and, depending on the sample type, in low abundance. This requires the application of specialized measures during molecular experiments and computational analyses. Furthermore, researchers often work with finite sample sizes, which impedes optimal experimental design and control of confounding factors, and with ethically sensitive samples necessitating the consideration of additional guidelines. In September 2020, early career researchers in the field of ancient metagenomics met (Standards, Precautions & Advances in Ancient Metagenomics 2 [SPAAM2] community meeting) to discuss the state of the field and how to address current challenges. Here, in an effort to bridge the gap between ancient and modern metagenomics, we highlight and reflect upon some common misconceptions, provide a brief overview of the challenges in our field, and point toward useful resources for potential reviewers and newcomers to the field.
AB - Like modern metagenomics, ancient metagenomics is a highly data-rich discipline, with the added challenge that the DNA of interest is degraded and, depending on the sample type, in low abundance. This requires the application of specialized measures during molecular experiments and computational analyses. Furthermore, researchers often work with finite sample sizes, which impedes optimal experimental design and control of confounding factors, and with ethically sensitive samples necessitating the consideration of additional guidelines. In September 2020, early career researchers in the field of ancient metagenomics met (Standards, Precautions & Advances in Ancient Metagenomics 2 [SPAAM2] community meeting) to discuss the state of the field and how to address current challenges. Here, in an effort to bridge the gap between ancient and modern metagenomics, we highlight and reflect upon some common misconceptions, provide a brief overview of the challenges in our field, and point toward useful resources for potential reviewers and newcomers to the field.
KW - Ancient DNA
KW - Ancient metagenomics
KW - Archaeogenomics
KW - Archaeology
KW - Authentication
KW - Cultural heritage
KW - Ethics
KW - Metagenomics
KW - Microbe
KW - Microbiome
KW - Paleogenetics
KW - Peer review
U2 - 10.1128/MSYSTEMS.01315-21
DO - 10.1128/MSYSTEMS.01315-21
M3 - Journal article
AN - SCOPUS:85122680235
VL - 6
JO - mSystems
JF - mSystems
SN - 2379-5077
IS - 6
M1 - e01315-21
ER -
ID: 291739223