Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes

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Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes. / Hansen, Sara Krogh; Nielsen, Eva-Maria D; Ek, Jakob; Andersen, Gitte; Glümer, Charlotte; Carstensen, Bendix; Mouritzen, Peter; Drivsholm, Thomas; Borch-Johnsen, Knut; Jørgensen, Torben; Hansen, Torben; Pedersen, Oluf.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 6, 01.06.2005, p. 3629-37.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, SK, Nielsen, E-MD, Ek, J, Andersen, G, Glümer, C, Carstensen, B, Mouritzen, P, Drivsholm, T, Borch-Johnsen, K, Jørgensen, T, Hansen, T & Pedersen, O 2005, 'Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes', Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3629-37. https://doi.org/10.1210/jc.2004-1942

APA

Hansen, S. K., Nielsen, E-M. D., Ek, J., Andersen, G., Glümer, C., Carstensen, B., Mouritzen, P., Drivsholm, T., Borch-Johnsen, K., Jørgensen, T., Hansen, T., & Pedersen, O. (2005). Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 90(6), 3629-37. https://doi.org/10.1210/jc.2004-1942

Vancouver

Hansen SK, Nielsen E-MD, Ek J, Andersen G, Glümer C, Carstensen B et al. Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. 2005 Jun 1;90(6):3629-37. https://doi.org/10.1210/jc.2004-1942

Author

Hansen, Sara Krogh ; Nielsen, Eva-Maria D ; Ek, Jakob ; Andersen, Gitte ; Glümer, Charlotte ; Carstensen, Bendix ; Mouritzen, Peter ; Drivsholm, Thomas ; Borch-Johnsen, Knut ; Jørgensen, Torben ; Hansen, Torben ; Pedersen, Oluf. / Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes. In: Journal of Clinical Endocrinology and Metabolism. 2005 ; Vol. 90, No. 6. pp. 3629-37.

Bibtex

@article{50e6efcbef984e77b0c73cd8ead2df9e,
title = "Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes",
abstract = "The separate and combined effects of the PPARG Pro(12)Ala polymorphism and the KCNJ11 Glu(23)Lys polymorphisms on risk of type 2 diabetes were investigated in relatively large-scale, case-control studies. Separate effects of the variants were examined among 1187/1461 type 2 diabetic patients and 4791/4986 middle-aged, glucose-tolerant subjects. The combined analysis involved 1164 type 2 diabetic patients and 4733 middle-aged, glucose-tolerant subjects. In the separate analyses, the K allele of the KCNJ11 Glu(23)Lys associated with type 2 diabetes (odds ratio, 1.19; P = 0.0002), whereas the PPARG Pro(12)Ala showed no significant association with type 2 diabetes. The combined analysis indicated that the two polymorphisms acted in an additive manner to increase the risk of type 2 diabetes, and we found no evidence for a synergistic interaction between them. Analysis of a model with equal additive effects of the two variants showed that the odds ratio for type 2 diabetes increased with 1.14/risk allele (P = 0.003). Together, the two polymorphisms conferred a population-attributable risk for type 2 diabetes of 28%. In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes.",
author = "Hansen, {Sara Krogh} and Nielsen, {Eva-Maria D} and Jakob Ek and Gitte Andersen and Charlotte Gl{\"u}mer and Bendix Carstensen and Peter Mouritzen and Thomas Drivsholm and Knut Borch-Johnsen and Torben J{\o}rgensen and Torben Hansen and Oluf Pedersen",
year = "2005",
month = jun,
day = "1",
doi = "10.1210/jc.2004-1942",
language = "English",
volume = "90",
pages = "3629--37",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes

AU - Hansen, Sara Krogh

AU - Nielsen, Eva-Maria D

AU - Ek, Jakob

AU - Andersen, Gitte

AU - Glümer, Charlotte

AU - Carstensen, Bendix

AU - Mouritzen, Peter

AU - Drivsholm, Thomas

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2005/6/1

Y1 - 2005/6/1

N2 - The separate and combined effects of the PPARG Pro(12)Ala polymorphism and the KCNJ11 Glu(23)Lys polymorphisms on risk of type 2 diabetes were investigated in relatively large-scale, case-control studies. Separate effects of the variants were examined among 1187/1461 type 2 diabetic patients and 4791/4986 middle-aged, glucose-tolerant subjects. The combined analysis involved 1164 type 2 diabetic patients and 4733 middle-aged, glucose-tolerant subjects. In the separate analyses, the K allele of the KCNJ11 Glu(23)Lys associated with type 2 diabetes (odds ratio, 1.19; P = 0.0002), whereas the PPARG Pro(12)Ala showed no significant association with type 2 diabetes. The combined analysis indicated that the two polymorphisms acted in an additive manner to increase the risk of type 2 diabetes, and we found no evidence for a synergistic interaction between them. Analysis of a model with equal additive effects of the two variants showed that the odds ratio for type 2 diabetes increased with 1.14/risk allele (P = 0.003). Together, the two polymorphisms conferred a population-attributable risk for type 2 diabetes of 28%. In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes.

AB - The separate and combined effects of the PPARG Pro(12)Ala polymorphism and the KCNJ11 Glu(23)Lys polymorphisms on risk of type 2 diabetes were investigated in relatively large-scale, case-control studies. Separate effects of the variants were examined among 1187/1461 type 2 diabetic patients and 4791/4986 middle-aged, glucose-tolerant subjects. The combined analysis involved 1164 type 2 diabetic patients and 4733 middle-aged, glucose-tolerant subjects. In the separate analyses, the K allele of the KCNJ11 Glu(23)Lys associated with type 2 diabetes (odds ratio, 1.19; P = 0.0002), whereas the PPARG Pro(12)Ala showed no significant association with type 2 diabetes. The combined analysis indicated that the two polymorphisms acted in an additive manner to increase the risk of type 2 diabetes, and we found no evidence for a synergistic interaction between them. Analysis of a model with equal additive effects of the two variants showed that the odds ratio for type 2 diabetes increased with 1.14/risk allele (P = 0.003). Together, the two polymorphisms conferred a population-attributable risk for type 2 diabetes of 28%. In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes.

U2 - 10.1210/jc.2004-1942

DO - 10.1210/jc.2004-1942

M3 - Journal article

C2 - 15797964

VL - 90

SP - 3629

EP - 3637

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 6

ER -

ID: 33030287