Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies

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Analgesic effects of melatonin : a review of current evidence from experimental and clinical studies. / Wilhelmsen, Michael; Amirian, Ilda; Reiter, Russel J; Rosenberg, Jacob; Gögenur, Ismail.

In: Journal of Pineal Research, Vol. 51, No. 3, 2011, p. 270-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wilhelmsen, M, Amirian, I, Reiter, RJ, Rosenberg, J & Gögenur, I 2011, 'Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies', Journal of Pineal Research, vol. 51, no. 3, pp. 270-7. https://doi.org/10.1111/j.1600-079X.2011.00895.x

APA

Wilhelmsen, M., Amirian, I., Reiter, R. J., Rosenberg, J., & Gögenur, I. (2011). Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. Journal of Pineal Research, 51(3), 270-7. https://doi.org/10.1111/j.1600-079X.2011.00895.x

Vancouver

Wilhelmsen M, Amirian I, Reiter RJ, Rosenberg J, Gögenur I. Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. Journal of Pineal Research. 2011;51(3):270-7. https://doi.org/10.1111/j.1600-079X.2011.00895.x

Author

Wilhelmsen, Michael ; Amirian, Ilda ; Reiter, Russel J ; Rosenberg, Jacob ; Gögenur, Ismail. / Analgesic effects of melatonin : a review of current evidence from experimental and clinical studies. In: Journal of Pineal Research. 2011 ; Vol. 51, No. 3. pp. 270-7.

Bibtex

@article{ade10c6b692d417bb90dec6a42f3594b,
title = "Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies",
abstract = "Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin shows potent analgesic effects in a dose-dependent manner. In clinical studies, melatonin has been shown to have analgesic benefits in patients with chronic pain (fibromyalgia, irritable bowel syndrome, migraine). The physiologic mechanism underlying the analgesic actions of melatonin has not been clarified. The effects may be linked to G(i) -coupled melatonin receptors, to G(i) -coupled opioid µ-receptors or GABA-B receptors with unknown downstream changes with a consequential reduction in anxiety and pain. Also, the repeated administration of melatonin improves sleep and thereby may reduce anxiety, which leads to lower levels of pain. In this paper, we review the current evidence regarding the analgesic properties of melatonin in animals and humans with chronic pain.",
author = "Michael Wilhelmsen and Ilda Amirian and Reiter, {Russel J} and Jacob Rosenberg and Ismail G{\"o}genur",
note = "{\textcopyright} 2011 John Wiley & Sons A/S.",
year = "2011",
doi = "http://dx.doi.org/10.1111/j.1600-079X.2011.00895.x",
language = "English",
volume = "51",
pages = "270--7",
journal = "Journal of Pineal Research (Print)",
issn = "0742-3098",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Analgesic effects of melatonin

T2 - a review of current evidence from experimental and clinical studies

AU - Wilhelmsen, Michael

AU - Amirian, Ilda

AU - Reiter, Russel J

AU - Rosenberg, Jacob

AU - Gögenur, Ismail

N1 - © 2011 John Wiley & Sons A/S.

PY - 2011

Y1 - 2011

N2 - Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin shows potent analgesic effects in a dose-dependent manner. In clinical studies, melatonin has been shown to have analgesic benefits in patients with chronic pain (fibromyalgia, irritable bowel syndrome, migraine). The physiologic mechanism underlying the analgesic actions of melatonin has not been clarified. The effects may be linked to G(i) -coupled melatonin receptors, to G(i) -coupled opioid µ-receptors or GABA-B receptors with unknown downstream changes with a consequential reduction in anxiety and pain. Also, the repeated administration of melatonin improves sleep and thereby may reduce anxiety, which leads to lower levels of pain. In this paper, we review the current evidence regarding the analgesic properties of melatonin in animals and humans with chronic pain.

AB - Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin shows potent analgesic effects in a dose-dependent manner. In clinical studies, melatonin has been shown to have analgesic benefits in patients with chronic pain (fibromyalgia, irritable bowel syndrome, migraine). The physiologic mechanism underlying the analgesic actions of melatonin has not been clarified. The effects may be linked to G(i) -coupled melatonin receptors, to G(i) -coupled opioid µ-receptors or GABA-B receptors with unknown downstream changes with a consequential reduction in anxiety and pain. Also, the repeated administration of melatonin improves sleep and thereby may reduce anxiety, which leads to lower levels of pain. In this paper, we review the current evidence regarding the analgesic properties of melatonin in animals and humans with chronic pain.

U2 - http://dx.doi.org/10.1111/j.1600-079X.2011.00895.x

DO - http://dx.doi.org/10.1111/j.1600-079X.2011.00895.x

M3 - Journal article

VL - 51

SP - 270

EP - 277

JO - Journal of Pineal Research (Print)

JF - Journal of Pineal Research (Print)

SN - 0742-3098

IS - 3

ER -

ID: 40192333