Amphotericin B and the blood-brain barrier to methotrexate

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Amphotericin B and the blood-brain barrier to methotrexate. / Barry, D I; Paulson, O B.

In: Neurosurgery, Vol. 10, No. 2, 02.1982, p. 224-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Barry, DI & Paulson, OB 1982, 'Amphotericin B and the blood-brain barrier to methotrexate', Neurosurgery, vol. 10, no. 2, pp. 224-6.

APA

Barry, D. I., & Paulson, O. B. (1982). Amphotericin B and the blood-brain barrier to methotrexate. Neurosurgery, 10(2), 224-6.

Vancouver

Barry DI, Paulson OB. Amphotericin B and the blood-brain barrier to methotrexate. Neurosurgery. 1982 Feb;10(2):224-6.

Author

Barry, D I ; Paulson, O B. / Amphotericin B and the blood-brain barrier to methotrexate. In: Neurosurgery. 1982 ; Vol. 10, No. 2. pp. 224-6.

Bibtex

@article{1dc5a9d571bd4e2ba712cf8ca87c13c0,
title = "Amphotericin B and the blood-brain barrier to methotrexate",
abstract = "The permeability of the blood-brain barrier (BBB) to methotrexate, Na+, and Cl- was studied in rats treated with the membrane-active antifungal agent amphotericin B. Enhancement of brain uptake of methotrexate was expected as amphotericin B increases the permeability of lipid membranes, including tumor cell membranes. However, amphotericin B had no effect of the BBB permeability to methotrexate, Na+, and Cl-. This may have been because the amphotericin B acted only on the luminal and not on the abluminal brain capillary membrane, leaving the BBB intact.",
keywords = "Amphotericin B/pharmacology, Animals, Antineoplastic Agents/administration & dosage, Blood-Brain Barrier/drug effects, Brain Neoplasms/drug therapy, Chlorides/metabolism, Drug Therapy, Combination, Male, Methotrexate/metabolism, Rats, Rats, Inbred Strains, Sodium/metabolism",
author = "Barry, {D I} and Paulson, {O B}",
year = "1982",
month = feb,
language = "English",
volume = "10",
pages = "224--6",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams & Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Amphotericin B and the blood-brain barrier to methotrexate

AU - Barry, D I

AU - Paulson, O B

PY - 1982/2

Y1 - 1982/2

N2 - The permeability of the blood-brain barrier (BBB) to methotrexate, Na+, and Cl- was studied in rats treated with the membrane-active antifungal agent amphotericin B. Enhancement of brain uptake of methotrexate was expected as amphotericin B increases the permeability of lipid membranes, including tumor cell membranes. However, amphotericin B had no effect of the BBB permeability to methotrexate, Na+, and Cl-. This may have been because the amphotericin B acted only on the luminal and not on the abluminal brain capillary membrane, leaving the BBB intact.

AB - The permeability of the blood-brain barrier (BBB) to methotrexate, Na+, and Cl- was studied in rats treated with the membrane-active antifungal agent amphotericin B. Enhancement of brain uptake of methotrexate was expected as amphotericin B increases the permeability of lipid membranes, including tumor cell membranes. However, amphotericin B had no effect of the BBB permeability to methotrexate, Na+, and Cl-. This may have been because the amphotericin B acted only on the luminal and not on the abluminal brain capillary membrane, leaving the BBB intact.

KW - Amphotericin B/pharmacology

KW - Animals

KW - Antineoplastic Agents/administration & dosage

KW - Blood-Brain Barrier/drug effects

KW - Brain Neoplasms/drug therapy

KW - Chlorides/metabolism

KW - Drug Therapy, Combination

KW - Male

KW - Methotrexate/metabolism

KW - Rats

KW - Rats, Inbred Strains

KW - Sodium/metabolism

M3 - Journal article

C2 - 7070618

VL - 10

SP - 224

EP - 226

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 2

ER -

ID: 279596784