Amount of Pneumocystis carinii and degree of acute lung inflammation in HIV-associated P carinii pneumonia.

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Standard

Amount of Pneumocystis carinii and degree of acute lung inflammation in HIV-associated P carinii pneumonia. / Vestbo, Jørgen; Nielsen, T L; Junge, Jette; Lundgren, Jens Dilling.

In: Chest, Vol. 104, No. 1, 1993, p. 109-113.

Research output: Contribution to journal › Journal article › Research

Harvard

Vestbo, J, Nielsen, TL, Junge, J & Lundgren, JD 1993, 'Amount of Pneumocystis carinii and degree of acute lung inflammation in HIV-associated P carinii pneumonia.', Chest, vol. 104, no. 1, pp. 109-113. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8100757&query_hl=25>

APA

Vestbo, J., Nielsen, T. L., Junge, J., & Lundgren, J. D. (1993). Amount of Pneumocystis carinii and degree of acute lung inflammation in HIV-associated P carinii pneumonia. Chest, 104(1), 109-113. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8100757&query_hl=25

Vancouver

Vestbo J, Nielsen TL, Junge J, Lundgren JD. Amount of Pneumocystis carinii and degree of acute lung inflammation in HIV-associated P carinii pneumonia. Chest. 1993;104(1):109-113.

Author

Vestbo, Jørgen ; Nielsen, T L ; Junge, Jette ; Lundgren, Jens Dilling. / Amount of Pneumocystis carinii and degree of acute lung inflammation in HIV-associated P carinii pneumonia. In: Chest. 1993 ; Vol. 104, No. 1. pp. 109-113.

Bibtex

@article{0b66fa8430d3420e89a6ab680d8096cf,
title = "Amount of Pneumocystis carinii and degree of acute lung inflammation in HIV-associated P carinii pneumonia.",
abstract = "Correlations between semiquantitative amounts of Pneumocystis carinii (PC), the degree of inflammation, and the severity of pneumonia were analyzed in 58 patients with PC pneumonia (PCP). Material from both transbronchial biopsies (TBBs; n = 39) and bronchoalveolar lavage fluid (BALF; n = 57) was examined. In the TBB the amount of PC correlated strongly with overall inflammation in the interstitium (Kendall correlation coefficient [Kcc] = 0.59; p < 0.0001), type 2 pneumocyte proliferation, and edema formation. The amount of PC in the TBB also correlated with interstitial accumulation of neutrophils (Kcc = 0.54; p = 0.0001), lymphocytes, and macrophages. In BALF the amount of PC correlated with edema formation and type 2 pneumocyte proliferation in the TBB but not with the percentage of neutrophils, lymphocytes, or macrophages in BALF. The amount of PC in the BALF and the percentage of neutrophils in the BALF correlated significantly with Po2 and the serum lactate dehydrogenase (LDH) level. Neither short-term nor long-term survival was affected by the amount of PC, inflammatory markers in the TBB, inflammatory cells in BALF, Po2, or the serum LDH levels. In conclusion, the amount of PC is associated with the extent of the acute inflammatory reaction in the lung in PCP associated with human immunodeficiency virus (HIV).",
author = "J{\o}rgen Vestbo and Nielsen, {T L} and Jette Junge and Lundgren, {Jens Dilling}",
year = "1993",
language = "English",
volume = "104",
pages = "109--113",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "1",

}

RIS

TY - JOUR

T1 - Amount of Pneumocystis carinii and degree of acute lung inflammation in HIV-associated P carinii pneumonia.

AU - Vestbo, Jørgen

AU - Nielsen, T L

AU - Junge, Jette

AU - Lundgren, Jens Dilling

PY - 1993

Y1 - 1993

N2 - Correlations between semiquantitative amounts of Pneumocystis carinii (PC), the degree of inflammation, and the severity of pneumonia were analyzed in 58 patients with PC pneumonia (PCP). Material from both transbronchial biopsies (TBBs; n = 39) and bronchoalveolar lavage fluid (BALF; n = 57) was examined. In the TBB the amount of PC correlated strongly with overall inflammation in the interstitium (Kendall correlation coefficient [Kcc] = 0.59; p < 0.0001), type 2 pneumocyte proliferation, and edema formation. The amount of PC in the TBB also correlated with interstitial accumulation of neutrophils (Kcc = 0.54; p = 0.0001), lymphocytes, and macrophages. In BALF the amount of PC correlated with edema formation and type 2 pneumocyte proliferation in the TBB but not with the percentage of neutrophils, lymphocytes, or macrophages in BALF. The amount of PC in the BALF and the percentage of neutrophils in the BALF correlated significantly with Po2 and the serum lactate dehydrogenase (LDH) level. Neither short-term nor long-term survival was affected by the amount of PC, inflammatory markers in the TBB, inflammatory cells in BALF, Po2, or the serum LDH levels. In conclusion, the amount of PC is associated with the extent of the acute inflammatory reaction in the lung in PCP associated with human immunodeficiency virus (HIV).

AB - Correlations between semiquantitative amounts of Pneumocystis carinii (PC), the degree of inflammation, and the severity of pneumonia were analyzed in 58 patients with PC pneumonia (PCP). Material from both transbronchial biopsies (TBBs; n = 39) and bronchoalveolar lavage fluid (BALF; n = 57) was examined. In the TBB the amount of PC correlated strongly with overall inflammation in the interstitium (Kendall correlation coefficient [Kcc] = 0.59; p < 0.0001), type 2 pneumocyte proliferation, and edema formation. The amount of PC in the TBB also correlated with interstitial accumulation of neutrophils (Kcc = 0.54; p = 0.0001), lymphocytes, and macrophages. In BALF the amount of PC correlated with edema formation and type 2 pneumocyte proliferation in the TBB but not with the percentage of neutrophils, lymphocytes, or macrophages in BALF. The amount of PC in the BALF and the percentage of neutrophils in the BALF correlated significantly with Po2 and the serum lactate dehydrogenase (LDH) level. Neither short-term nor long-term survival was affected by the amount of PC, inflammatory markers in the TBB, inflammatory cells in BALF, Po2, or the serum LDH levels. In conclusion, the amount of PC is associated with the extent of the acute inflammatory reaction in the lung in PCP associated with human immunodeficiency virus (HIV).

M3 - Journal article

VL - 104

SP - 109

EP - 113

JO - Chest

JF - Chest

SN - 0012-3692

IS - 1

ER -

ID: 34128515