Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids
Research output: Contribution to journal › Journal article › Research › peer-review
[Structure: see text] Solid-phase synthesis is a rapidly developing area of organic chemistry, of particular importance for medicinal chemistry and chemical biology. Aziridines have previously only rarely been applied in solid-phase synthesis. In the present work, aminolysis of resin-bound, spring-loaded N-nitrobenzenesulfonyl-activated aziridine-2-carboxylic acids has been optimized and employed in the synthesis of a number of open-chain and heterocyclic scaffolds, including enantiopure products.
Original language | English |
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Journal | Organic Letters |
Volume | 8 |
Issue number | 15 |
Pages (from-to) | 3371-4 |
Number of pages | 4 |
ISSN | 1523-7060 |
DOIs | |
Publication status | Published - 2006 |
- Amino Alcohols, Aziridines, Carboxylic Acids, Heterocyclic Compounds, Molecular Structure, Stereoisomerism
Research areas
ID: 42352810