Alcohol consumption and risk of psoriasis: Results from observational and genetic analyses in more than 100,000 individuals from the Danish general population
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Alcohol consumption and risk of psoriasis : Results from observational and genetic analyses in more than 100,000 individuals from the Danish general population. / Jordan, Alexander; Näslund-Koch, Charlotte; Vedel-Krogh, Signe; Egil Bojesen, Stig; Skov, Lone.
In: JAAD International, Vol. 15, 2024, p. 197-205.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Alcohol consumption and risk of psoriasis
T2 - Results from observational and genetic analyses in more than 100,000 individuals from the Danish general population
AU - Jordan, Alexander
AU - Näslund-Koch, Charlotte
AU - Vedel-Krogh, Signe
AU - Egil Bojesen, Stig
AU - Skov, Lone
N1 - Publisher Copyright: © 2024 American Academy of Dermatology, Inc.
PY - 2024
Y1 - 2024
N2 - Background: Psoriasis is associated with high alcohol consumption, but the causality of this relationship is unclear. Objective: We aimed to use a Mendelian randomization approach to investigate the causal effects of alcohol on incident psoriasis. Methods: We included 102,655 adults from the prospective Copenhagen studies. All participants filled out a questionnaire on alcohol consumption, were physically examined, and had blood drawn for biochemical and genetic analyses. We created a genetic instrument based on the number of fast-metabolizing alleles in alcohol dehydrogenase 1B and alcohol dehydrogenase 1C, known to be associated with alcohol consumption, to test whether alcohol consumption was causally associated with psoriasis. Results: Observationally, we found an increased risk of incident psoriasis among individuals with high alcohol consumption compared to those with low alcohol consumption with a hazard ratio of 1.30 (95% confidence interval 1.05-1.60) in the fully adjusted model. Using genetic data to predict alcohol consumption to avoid confounding and reverse causation, we found no association between number of fast-metabolizing alleles and risk of psoriasis. Limitations: Alcohol consumption was self-reported and psoriasis was defined using the International Classification of Diseases 10th revision and 8th revision codes. Conclusion: Alcohol consumption is observationally but not causally associated with incident psoriasis.
AB - Background: Psoriasis is associated with high alcohol consumption, but the causality of this relationship is unclear. Objective: We aimed to use a Mendelian randomization approach to investigate the causal effects of alcohol on incident psoriasis. Methods: We included 102,655 adults from the prospective Copenhagen studies. All participants filled out a questionnaire on alcohol consumption, were physically examined, and had blood drawn for biochemical and genetic analyses. We created a genetic instrument based on the number of fast-metabolizing alleles in alcohol dehydrogenase 1B and alcohol dehydrogenase 1C, known to be associated with alcohol consumption, to test whether alcohol consumption was causally associated with psoriasis. Results: Observationally, we found an increased risk of incident psoriasis among individuals with high alcohol consumption compared to those with low alcohol consumption with a hazard ratio of 1.30 (95% confidence interval 1.05-1.60) in the fully adjusted model. Using genetic data to predict alcohol consumption to avoid confounding and reverse causation, we found no association between number of fast-metabolizing alleles and risk of psoriasis. Limitations: Alcohol consumption was self-reported and psoriasis was defined using the International Classification of Diseases 10th revision and 8th revision codes. Conclusion: Alcohol consumption is observationally but not causally associated with incident psoriasis.
KW - ADH1B
KW - ADH1C
KW - alcohol
KW - epidemiology
KW - Mendelian randomization
KW - psoriasis
KW - risk factors
U2 - 10.1016/j.jdin.2024.03.003
DO - 10.1016/j.jdin.2024.03.003
M3 - Journal article
C2 - 38707928
AN - SCOPUS:85191246678
VL - 15
SP - 197
EP - 205
JO - JAAD International
JF - JAAD International
SN - 2666-3287
ER -
ID: 391163521