Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET. / Asserhøj, Louise Laub; Spangmose, Anne Lærke; Aaris Henningsen, Anna Karina; Clausen, Tine Dalsgaard; Ziebe, Søren; Jensen, Rikke Beck; Pinborg, Anja.

In: Fertility and Sterility, Vol. 115, No. 4, 04.2021, p. 947-956.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Asserhøj, LL, Spangmose, AL, Aaris Henningsen, AK, Clausen, TD, Ziebe, S, Jensen, RB & Pinborg, A 2021, 'Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET', Fertility and Sterility, vol. 115, no. 4, pp. 947-956. https://doi.org/10.1016/j.fertnstert.2020.10.039

APA

Asserhøj, L. L., Spangmose, A. L., Aaris Henningsen, A. K., Clausen, T. D., Ziebe, S., Jensen, R. B., & Pinborg, A. (2021). Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET. Fertility and Sterility, 115(4), 947-956. https://doi.org/10.1016/j.fertnstert.2020.10.039

Vancouver

Asserhøj LL, Spangmose AL, Aaris Henningsen AK, Clausen TD, Ziebe S, Jensen RB et al. Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET. Fertility and Sterility. 2021 Apr;115(4):947-956. https://doi.org/10.1016/j.fertnstert.2020.10.039

Author

Asserhøj, Louise Laub ; Spangmose, Anne Lærke ; Aaris Henningsen, Anna Karina ; Clausen, Tine Dalsgaard ; Ziebe, Søren ; Jensen, Rikke Beck ; Pinborg, Anja. / Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET. In: Fertility and Sterility. 2021 ; Vol. 115, No. 4. pp. 947-956.

Bibtex

@article{8fc4a2d5ee3b492bac04975b54016825,

title = "Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET",

abstract = "Objective: To investigate whether obstetric and perinatal outcomes in pregnancies differ after different frozen embryo transfer (FET) protocols. Design: Register-based cohort study. Setting: Not applicable. Patient(s): All singleton deliveries after assisted reproductive technology in Denmark from 2006 to 2014. Data consisted of 1,136 deliveries after frozen in vitro fertilization. Frozen embryo transfer cycles were grouped by type of FET protocol: programmed FET (n = 357); modified natural cycle FET (n = 611); and true natural cycle FET (n = 168). Intervention(s): None. Main Outcome Measure(s): Obstetric outcomes (hypertensive disorders in pregnancy, preterm prelabor rupture of membranes, placenta previa, placental abruption, induction of labor, postpartum hemorrhage, and cesarean section) and perinatal outcomes (post-term birth, preterm birth, birth weight, small for gestational age, large for gestational age). Result(s): The risk of hypertensive disorders in pregnancy, postpartum hemorrhage, and cesarean section was significantly higher after programmed FET compared with natural cycle FET (modified natural cycle FET and true natural cycle FET). A higher risk of birth weight > 4,500 g was observed in the programmed FET group compared with natural cycle FET. Conclusion(s): This study shows that obstetric and perinatal outcomes are adversely affected in programmed FET cycles. Hence, when possible, an endometrial preparation with the creation of a corpus luteum should be considered. Properly sized randomized controlled trials of FET in programmed cycle versus natural cycle including perinatal outcomes are warranted in the future. Clinical Trial Registration Number: ISRCTN11780826.",

keywords = "Frozen embryo transfer (FET), natural cycle, obstetric outcome, perinatal outcome, programmed cycle",

author = "Asserh{\o}j, {Louise Laub} and Spangmose, {Anne L{\ae}rke} and {Aaris Henningsen}, {Anna Karina} and Clausen, {Tine Dalsgaard} and S{\o}ren Ziebe and Jensen, {Rikke Beck} and Anja Pinborg",

note = "Publisher Copyright: {\textcopyright} 2020 American Society for Reproductive Medicine",

year = "2021",

month = apr,

doi = "10.1016/j.fertnstert.2020.10.039",

language = "English",

volume = "115",

pages = "947--956",

journal = "Sexuality, Reproduction and Menopause",

issn = "1546-2501",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET

AU - Asserhøj, Louise Laub

AU - Spangmose, Anne Lærke

AU - Aaris Henningsen, Anna Karina

AU - Clausen, Tine Dalsgaard

AU - Ziebe, Søren

AU - Jensen, Rikke Beck

AU - Pinborg, Anja

PY - 2021/4

Y1 - 2021/4

N2 - Objective: To investigate whether obstetric and perinatal outcomes in pregnancies differ after different frozen embryo transfer (FET) protocols. Design: Register-based cohort study. Setting: Not applicable. Patient(s): All singleton deliveries after assisted reproductive technology in Denmark from 2006 to 2014. Data consisted of 1,136 deliveries after frozen in vitro fertilization. Frozen embryo transfer cycles were grouped by type of FET protocol: programmed FET (n = 357); modified natural cycle FET (n = 611); and true natural cycle FET (n = 168). Intervention(s): None. Main Outcome Measure(s): Obstetric outcomes (hypertensive disorders in pregnancy, preterm prelabor rupture of membranes, placenta previa, placental abruption, induction of labor, postpartum hemorrhage, and cesarean section) and perinatal outcomes (post-term birth, preterm birth, birth weight, small for gestational age, large for gestational age). Result(s): The risk of hypertensive disorders in pregnancy, postpartum hemorrhage, and cesarean section was significantly higher after programmed FET compared with natural cycle FET (modified natural cycle FET and true natural cycle FET). A higher risk of birth weight > 4,500 g was observed in the programmed FET group compared with natural cycle FET. Conclusion(s): This study shows that obstetric and perinatal outcomes are adversely affected in programmed FET cycles. Hence, when possible, an endometrial preparation with the creation of a corpus luteum should be considered. Properly sized randomized controlled trials of FET in programmed cycle versus natural cycle including perinatal outcomes are warranted in the future. Clinical Trial Registration Number: ISRCTN11780826.

AB - Objective: To investigate whether obstetric and perinatal outcomes in pregnancies differ after different frozen embryo transfer (FET) protocols. Design: Register-based cohort study. Setting: Not applicable. Patient(s): All singleton deliveries after assisted reproductive technology in Denmark from 2006 to 2014. Data consisted of 1,136 deliveries after frozen in vitro fertilization. Frozen embryo transfer cycles were grouped by type of FET protocol: programmed FET (n = 357); modified natural cycle FET (n = 611); and true natural cycle FET (n = 168). Intervention(s): None. Main Outcome Measure(s): Obstetric outcomes (hypertensive disorders in pregnancy, preterm prelabor rupture of membranes, placenta previa, placental abruption, induction of labor, postpartum hemorrhage, and cesarean section) and perinatal outcomes (post-term birth, preterm birth, birth weight, small for gestational age, large for gestational age). Result(s): The risk of hypertensive disorders in pregnancy, postpartum hemorrhage, and cesarean section was significantly higher after programmed FET compared with natural cycle FET (modified natural cycle FET and true natural cycle FET). A higher risk of birth weight > 4,500 g was observed in the programmed FET group compared with natural cycle FET. Conclusion(s): This study shows that obstetric and perinatal outcomes are adversely affected in programmed FET cycles. Hence, when possible, an endometrial preparation with the creation of a corpus luteum should be considered. Properly sized randomized controlled trials of FET in programmed cycle versus natural cycle including perinatal outcomes are warranted in the future. Clinical Trial Registration Number: ISRCTN11780826.

KW - Frozen embryo transfer (FET)

KW - natural cycle

KW - obstetric outcome

KW - perinatal outcome

KW - programmed cycle

U2 - 10.1016/j.fertnstert.2020.10.039

DO - 10.1016/j.fertnstert.2020.10.039

M3 - Journal article

C2 - 33461756

AN - SCOPUS:85099562209

VL - 115

SP - 947

EP - 956

JO - Sexuality, Reproduction and Menopause

JF - Sexuality, Reproduction and Menopause

SN - 1546-2501

IS - 4

ER -

ID: 285520759

Forskning