Advances in methods for identification and characterization of plant transporter function
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Advances in methods for identification and characterization of plant transporter function. / Larsen, Bo; Xu, Deyang; Halkier, Barbara Ann; Nour-Eldin, Hussam Hassan.
In: Journal of Experimental Botany, Vol. 68, No. 15, 2017, p. 4045-4056.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Advances in methods for identification and characterization of plant transporter function
AU - Larsen, Bo
AU - Xu, Deyang
AU - Halkier, Barbara Ann
AU - Nour-Eldin, Hussam Hassan
PY - 2017
Y1 - 2017
N2 - Transport proteins are crucial for cellular function at all levels. Numerous importers and exporters facilitate transport of a diverse array of metabolites and ions intra- and intercellularly. Identification of transporter function is essential for understanding biological processes at both the cellular and organismal level. Assignment of a functional role to individual transporter proteins or to identify a transporter with a given substrate specificity has notoriously been challenging. Recently, major advances have been achieved in function-driven screens, phenotype-driven screens, and in silico-based approaches. In this review, we highlight examples that illustrate how new technology and tools have advanced identification and characterization of plant transporter functions.
AB - Transport proteins are crucial for cellular function at all levels. Numerous importers and exporters facilitate transport of a diverse array of metabolites and ions intra- and intercellularly. Identification of transporter function is essential for understanding biological processes at both the cellular and organismal level. Assignment of a functional role to individual transporter proteins or to identify a transporter with a given substrate specificity has notoriously been challenging. Recently, major advances have been achieved in function-driven screens, phenotype-driven screens, and in silico-based approaches. In this review, we highlight examples that illustrate how new technology and tools have advanced identification and characterization of plant transporter functions.
U2 - 10.1093/jxb/erx140
DO - 10.1093/jxb/erx140
M3 - Review
C2 - 28472492
VL - 68
SP - 4045
EP - 4056
JO - Journal of Experimental Botany
JF - Journal of Experimental Botany
SN - 0022-0957
IS - 15
ER -
ID: 177302077