Acute Effects of Three Different Meal Patterns on Postprandial Metabolism in Older Individuals with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Controlled Crossover Trial
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- OA-Acute Effects of Three Different Meal Patterns on Postprandial Metabolism
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Scope: The aim of this study is to investigate acute postprandial responses to intake of meals typical for Mediterranean and Western diets. Methods: In a randomized crossover design, overweight and obese participants with a risk phenotype for cardiometabolic diseases consumed three different isoenergetic meals: Western diet-like high-fat (WDHF), Western diet-like high-carbohydrate (WDHC), and Mediterranean diet (MED) meal. Blood samples are collected at fasting and 1, 2, 3, 4, 5 h postprandially and analyzed for parameters of lipid and glucose metabolism, inflammation, oxidation, and antioxidant status. Results: Compared to MED and WDHF meals, intake of a WDHC meal results in prolonged and elevated increases in glucose and insulin. Elevations for triglycerides are enhanced after the WDHF meal compared to the MED and the WDHC meal. Glucagon-like peptide-1 and interleukin-6 increase postprandially without meal differences. Apart from vitamin C showing an increase after the MED meal and a decrease after WDHF and WDHC meals, antioxidant markers decrease postprandially without meal differences. Plasma interleukin-1β is not affected by meal intake. Conclusions: Energy-rich meals induce hyperglycemia, hyperlipemia, an inflammatory response, and a decrease in antioxidant markers. A meal typical for the Mediterranean diet results in favorable effects on glycemic, insulinemic, and lipemic responses.
Original language | English |
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Article number | 1901035 |
Journal | Molecular Nutrition & Food Research |
Volume | 64 |
Issue number | 9 |
Number of pages | 13 |
ISSN | 1613-4125 |
DOIs | |
Publication status | Published - 2020 |
- glucose response, inflammation, Mediterranean diet, triglyceride response, Western diet
Research areas
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