Active inter-cellular forces in collective cell motility
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Active inter-cellular forces in collective cell motility. / Zhang, Guanming; Mueller, Romain; Doostmohammadi, Amin; Yeomans, Julia M.
In: Journal of the Royal Society. Interface, Vol. 17, No. 169, 20200312, 26.08.2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Active inter-cellular forces in collective cell motility
AU - Zhang, Guanming
AU - Mueller, Romain
AU - Doostmohammadi, Amin
AU - Yeomans, Julia M.
PY - 2020/8/26
Y1 - 2020/8/26
N2 - The collective behaviour of confluent cell sheets is strongly influenced both by polar forces, arising through cytoskeletal propulsion, and by active inter-cellular forces, which are mediated by interactions across cell-cell junctions. We use a phase-field model to explore the interplay between these two contributions and compare the dynamics of a cell sheet when the polarity of the cells aligns to (i) their main axis of elongation, (ii) their velocity and (iii) when the polarity direction executes a persistent random walk. In all three cases, we observe a sharp transition from a jammed state (where cell rearrangements are strongly suppressed) to a liquid state (where the cells can move freely relative to each other) when either the polar or the inter-cellular forces are increased. In addition, for case (ii) only, we observe an additional dynamical state, flocking (solid or liquid), where the majority of the cells move in the same direction. The flocking state is seen for strong polar forces, but is destroyed as the strength of the inter-cellular activity is increased.
AB - The collective behaviour of confluent cell sheets is strongly influenced both by polar forces, arising through cytoskeletal propulsion, and by active inter-cellular forces, which are mediated by interactions across cell-cell junctions. We use a phase-field model to explore the interplay between these two contributions and compare the dynamics of a cell sheet when the polarity of the cells aligns to (i) their main axis of elongation, (ii) their velocity and (iii) when the polarity direction executes a persistent random walk. In all three cases, we observe a sharp transition from a jammed state (where cell rearrangements are strongly suppressed) to a liquid state (where the cells can move freely relative to each other) when either the polar or the inter-cellular forces are increased. In addition, for case (ii) only, we observe an additional dynamical state, flocking (solid or liquid), where the majority of the cells move in the same direction. The flocking state is seen for strong polar forces, but is destroyed as the strength of the inter-cellular activity is increased.
KW - active matter
KW - cell motility
KW - phase-field model
KW - MORPHOGENESIS
KW - POLARIZATION
KW - MIGRATION
U2 - 10.1098/rsif.2020.0312
DO - 10.1098/rsif.2020.0312
M3 - Journal article
C2 - 32781933
VL - 17
JO - Journal of the Royal Society. Interface
JF - Journal of the Royal Society. Interface
SN - 1742-5689
IS - 169
M1 - 20200312
ER -
ID: 248233494