ACE inhibitors and cerebral blood flow
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ACE inhibitors and cerebral blood flow. / Paulson, O B; Waldemar, G.
In: Journal of Human Hypertension, Vol. 4 Suppl 4, 10.1990, p. 69-72; discussion 72-3.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - ACE inhibitors and cerebral blood flow
AU - Paulson, O B
AU - Waldemar, G
PY - 1990/10
Y1 - 1990/10
N2 - Inhibition of angiotensin converting enzyme (ACE) shifts the limits of cerebral blood flow autoregulation towards lower blood pressure values. In patients with chronic arterial hypertension and in patients with chronic heart failure cerebral blood flow is not changed by acute or chronic ACE inhibition, despite, in some cases, pronounced reductions in the mean arterial blood pressure. ACE inhibition does not change ischaemic regional cerebral blood flow in acute stroke. It is concluded that following ACE inhibition cerebral blood flow is maintained at an unchanged level and especially well maintained in case of blood pressure drop.
AB - Inhibition of angiotensin converting enzyme (ACE) shifts the limits of cerebral blood flow autoregulation towards lower blood pressure values. In patients with chronic arterial hypertension and in patients with chronic heart failure cerebral blood flow is not changed by acute or chronic ACE inhibition, despite, in some cases, pronounced reductions in the mean arterial blood pressure. ACE inhibition does not change ischaemic regional cerebral blood flow in acute stroke. It is concluded that following ACE inhibition cerebral blood flow is maintained at an unchanged level and especially well maintained in case of blood pressure drop.
KW - Angiotensin-Converting Enzyme Inhibitors/pharmacology
KW - Cerebrovascular Circulation/drug effects
KW - Hemodynamics/drug effects
KW - Humans
KW - Hypertension/drug therapy
M3 - Review
C2 - 2283657
VL - 4 Suppl 4
SP - 69-72; discussion 72-3
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
SN - 0950-9240
ER -
ID: 275281802